Psilocybin and depression

Awareness that psilocybin sessions are a very strong treatment method against depression is on the rise. Scientific studies are increasingly showing that psilocybin is most effective for treatment-resistant depression. All these studies are based on a single high dose of psilocybin without lifestyle modifications. What would happen if all test subjects outside the psilocybin session were also advised to live healthier lives?

The trip therapy treatment for depression

Most of our clients suffer from depression. From the working experience of trip therapy, we learn that the results in depression treatments with psychedelics such as psilocybin works even better if we create a plan of action to promote physical and mental health. We do this in trip therapy based on an intake and neurotransmitter question test so that we can improve the neurochemistry of the brain even before the psychedelic session. This along with some extra preparation ensures a good foundation and a better psychedelic session.

Timeline trip therapy



During registration, an intake form is completed and questionnaire about your state of mind, called the neurotransmitter test.

2 weeks before the session


Within a few days we will contact you to advise you. The advice will cover nutrition, supplements and possibly exercise advice.

1 week before the session


After following the advice, there is contact again after about a week about the progress and effect of the advice. Here we can still decide to change the schedule if necessary.

Additional suggestions
3 days before the session

Additional Suggestions

The three days before your session are the most important days of your preparation. Dot the "i" here and we will give you additional tips. For example, certain things to read or videos to watch.

Assignment and information
1 day before the session

Assignment and information

The day before the psychedelic session you will be given information about the day of the session. For example about what you may and may not eat before and after your session. Also, if it helps, we can give you an extra small assignment to make the session even more effective.

Half an hour before the session
30 minutes before the session

Before the session

On the day of the ceremony, we will meet as arranged and conduct the session. This is an important day and we will talk about intentions and goals for about half an hour, or longer if needed. Also, here we prepare you for what to expect and how to handle certain situations.

The intake
The psychedelic session

The intake

As soon as you are ready, you can take the psychedelics we provide. We will stay in conversation and keep an eye on the goals.

The first effects
15-30 minutes after ingestion

The first effects

After only about 15 minutes, the first psychedelic effects may appear. This can range from optical disturbances, the coming up of various feelings. Some experience the beginning as something very nice and others find it unpleasant. During this phase, your coach will help you relax, as relaxation plays the key role in beginning the psychedelic journey.

The peak
60-90 minutes after ingestion

The introspection

After about an hour to an hour and a half after ingestion, the peak of psychedelic effects will set in. This peak is perfect for turning more inward. The coach will give you space for introspection during this phase. Every now and then you can expect a question that you may not be able and need to answer with words. As needed, this phase may take as little as 30 minutes or as long as two hours.

After the peak
2-5 hours after ingestion

Coming down

During the coming down, gradually the whole perception will become as it was before the trip, but with some insights and positive changes. Depending on the dosage, the coming down occurs about a 2 hours after ingestion. During the coming down we will regain more contact.

End of session
4-10 hours after ingestion

Final discussion session

Once you are back on your feet we will have a wrap-up call for today. You may still experience mild effects from the psychedelics. These effects sometimes last for 12 hours after ingestion. Even though you can do almost anything again, we recommend that you take it easy and do not make any appointments.

Day after the session
Day after the session

Rest Day

The day after the psychedelic session can be a day with either high or low energy. We recommend that you keep this day free just to be safe.

The days after the session


The days after the session we will be in touch about the experience and what you could do with it in daily life.

For whom is psilocybin therapy not suitable?

Psilocybin and certain medications definitely cannot go together. Also, there are a few other physical contraindications to consider. Furthermore, some mental disorders can be aggravated by the use of psychedelics. Here are the contraindications.


  • High blood pressure
  • Cardiovascular diseases
  • Brain Hemorrhage
  • Pregnancy


  • Schizophrenia
  • Psychosis(susceptibility)
  • Borderline


  • SSRi: citalopram (Cipramil®) - escitalopram (Lexapro®) - fluoxetine (Prozac®) - fluvoxamine (Fevarin®) - paroxetine (Seroxat®) - sertraline (Zoloft®) etc...
  • SNRi: Venlafaxine (Efexor) - Duloxetine (Cymbalta) etc....
  • TCA: mitriptyline (Tryptizol®) - clomipramine (Anafranil®) - imipramine - nortriptyline (Nortrilen®) etc....
  • Benzodiazepines: oxazepam (Seresta), - diazepam (Valium) - alprazolam (Xanax) etc....
  • Drugs for high blood pressure: (methyldopa, guanethidine, reserpine)
  • Tramadol and similar drugs.

In case you are using a medication that cannot be combined with psychedelics, you can examine, in consultation with the prescribing physician, whether you can phase out this medication. So never just stop medication without consulting your doctor. A psychedelic session can take place two weeks after complete abstinence from the above medications.

First steps in depression treatments

Step 1

Slowly we can call depression an inflammatory disease. The decrease in serotonin, dopamine and GABA is often a result deficient in nutrients and/or from mild to severe inflammatory reactions in the body. Precisely in order to identify as many causes as possible, it is best to do as much good as possible. Let's start with a good diet that lowers the chances of nutrient deficiencies and inflammatory levels. Read the following blog to learn more about diet against depression.

The antidepression diet

Step 2

If you are allergic to certain foods or substances in the environment, it is good to avoid them as much as possible. This is because allergies also increase inflammatory levels and thus the risk of depression. Requesting an allergy screening can provide very useful information.

Step 3

During sleep, the body and brain are repaired. Sleeping well is important factor. During sleep, a hormone called BDNF is released, which restores brain areas that have typically declined in health because of depression. BDNF appears to play a greater role in preventing depression in men than in women.

Tips for better sleep

Step 4

Look at the image below and assess which causes of stress and therefore inflammation you can eliminate. The more you do well the better all parts of the fight against depression will work together.

Vrije radicalen -Depressie behandeling met psilocybine

Step 5

Implement our advice we give after registering for trip therapy for a period of 1-3 weeks.

Start the intake for trip therapy here

Step 6

The psychedelic session causes changes on the physical level. New connections are created in the brain through neurogenesis. This effect in itself improves the state of mind. In addition to these physical changes, insights gained during the psychedelic state can cause changes in thinking and behavior. All of these changes together produce the desired result. So change is the key to success in a world where the only thing that always stays the same is...... change.

How many psilocybin sessions are required?

For treatment against depression, most clients require only 1 or 2 sessions, with the first session often being lower dosage than the second. Between these sessions there is a period of about two months. These two months are used to work with the insights. Everyone does this in their own way.

How have other people experienced trip therapy for depression?

We have a number of reviews on the forum from customers who have undergone a psilocybin session to combat depression. Herewith the hyperlinks of some of the reviews:

Psilocybin therapy review

Trip therapy against depression

Tripping against depression

Medium truffle trip against depression

Trip therapy in Schiedam

How can we help you?

Everyone is unique and needs a slightly different approach. What other goals outside of depression treatment do you have? Often depression goes hand in hand with anxiety symptoms. In any case, let us know your overall place via intake or contact form so we can take a customized approach.