{"id":45536,"date":"2024-04-14T22:35:46","date_gmt":"2024-04-14T20:35:46","guid":{"rendered":"https:\/\/triptherapie.nl\/?p=45536"},"modified":"2024-09-26T14:52:30","modified_gmt":"2024-09-26T12:52:30","slug":"psilocybin-against-crohns-disease","status":"publish","type":"post","link":"https:\/\/triptherapie.nl\/en\/psilocybine-tegen-de-ziekte-van-crohn\/","title":{"rendered":"Psilocybin for Crohn's disease"},"content":{"rendered":"
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Psilocybin and Crohn's<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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An increasing number of scientific studies are confirming that psilocybin acts as an anti-inflammatory. Most natural treatments for Crohn's disease work because they possess these anti-inflammatory mechanisms. Could psilocybin therefore, as an anti-inflammatory at the cellular level, make a difference for individuals with Crohn's?<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tPsilocybin therapy<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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What is Crohn's disease?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Crohn's disease is a chronic inflammatory bowel disease that affects the digestive tract, causing abdominal pain, diarrhoea, fatigue, weight loss and malnutrition. The inflammation caused by Crohn's disease can affect any part of the digestive tract, from the mouth to the anus. These symptoms have a significant impact on patients' quality of life. Understanding the underlying causes and treatments of this condition is essential for finding a cure for this disease.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Possible causes<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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The causes of Crohn's disease are not yet fully known to date. However, scientific research has shown that factors such as heredity and a disturbed immune system likely play a role in the onset of the disease. Furthermore, risk factors such as age, ethnicity, family history, smoking, the use of anti-inflammatory medications, and certain environmental factors may contribute to the development of Crohn's disease. We therefore do not yet know everything about this condition, but thanks to scientific studies, we are increasingly understanding how the disease can manifest itself.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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What we do know about Crohn's<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Through measurements, it is known which inflammatory products occur in high concentrations in Crohn's disease. These products include C-reactive protein, interleukin-6 and tumour necrosis factor-alpha. These measurements enable us to better understand the disease and develop targeted treatments that counteract these inflammatory products.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Does psilocybin have an anti-inflammatory effect in Crohn's disease?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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According to various scientific studies, psilocybin can precisely lower the inflammatory markers that are elevated in Crohn's. In theory, this seems to be a solution to be able to reduce Crohn's symptoms and get the disease under control. Below, we indicate per topic whether psilocybin can have a positive influence on Crohn's inflammatory processes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tPsilocybin for inflammation<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t\"psilocybin\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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CRP<\/h4>\t\t\t\t<\/div>\n\t\t\t\t
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C-reactive protein remains lowered for a long time after using psilocybin.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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There is some evidence to suggest that lowering C-reactive protein (CRP) levels may potentially help in the treatment of Crohn's disease. Lowering CRP is an indication of reduced inflammation levels.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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IL-6<\/h4>\t\t\t\t<\/div>\n\t\t\t\t
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Interleukin-6 is also persistently decreased for a long time after using psilocybin.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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According to research, lowering IL-6 in people with Crohn's disease can either reduce or worsen symptoms. For now, it is unclear why this happens and further research is needed to get a clear picture.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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TNF-\u03b1<\/h4>\t\t\t\t<\/div>\n\t\t\t\t
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During the use of psilocybin, tumour necrosis factor-alpha is reduced.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Lowering TNF-\u03b1 can reduce inflammation and alleviate symptoms such as abdominal pain, diarrhoea and weight loss. Psilocybin reduces TNF-\u03b1 primarily during the use of high doses.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Tentative conclusion on the efficacy of psilocybin<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Lowering inflammation in the gut in Crohn's disease is seen as the best solution to counteract the harmfulness of Crohn's. Psilocybin can reduce various inflammatory factors. Whether psilocybin thereby contributes to reducing Crohn's must be further investigated. For example, a previous study showed that blocking IL-6 alone could contribute to exacerbation of the disease, which may be due to the selective blockade of solely IL-6. This is because IL-6 plays a dual role by both inhibiting and promoting inflammation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Whether it is wise to start using psilocybin for Crohn's disease is something we cannot, of course, say with certainty. We believe that psilocybin will primarily have an anti-inflammatory effect in Crohn's, but further research will need to tell us more about its activity and safety.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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What else can you do?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Besides the use of psilocybin, there are many other things that have anti-inflammatory properties and can therefore help with Crohn's disease. We provide a list of tips against Crohn's.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

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Herbal medicine<\/div>\n\t\t\t\t\t\t\t\t\t
Supplements<\/div>\n\t\t\t\t\t\t\t\t\t
Poor nutrition<\/div>\n\t\t\t\t\t\t\t\t\t
Allergens<\/div>\n\t\t\t\t\t\t\t\t\t
Stress<\/div>\n\t\t\t\t\t\t\t<\/div>\n\t\t\t
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Herbal medicine<\/div>\n\t\t\t\t\t