{"id":52956,"date":"2025-08-29T20:03:46","date_gmt":"2025-08-29T18:03:46","guid":{"rendered":"https:\/\/triptherapie.nl\/?p=52956"},"modified":"2025-08-29T20:03:59","modified_gmt":"2025-08-29T18:03:59","slug":"how-psilocybin-affects-gut-microbes","status":"publish","type":"post","link":"https:\/\/triptherapie.nl\/en\/hoe-psilocybine-de-microben-in-de-darmen-beinvloedt\/","title":{"rendered":"How psilocybin affects gut microbes"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"52956\" class=\"elementor elementor-52956\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-219c143 e-flex e-con-boxed e-con e-parent\" data-id=\"219c143\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aced939 elementor-widget elementor-widget-heading\" data-id=\"aced939\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"psilocybine-is-meer-dan-een-geestverruimend-middel\">Psilocybin is more than a mind-altering drug<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-45a9181 elementor-widget elementor-widget-text-editor\" data-id=\"45a9181\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Psilocybin is best known for its profound influence on consciousness, emotions, and spirituality. However, psilocybin&#039;s effects don&#039;t just occur in the brain. Once ingested, psilocybin first enters the intestines, where it is converted into <strong data-start=\"734\" data-end=\"747\">psilocin<\/strong>. This is the active ingredient that not only affects serotonergic receptors in the brain, but also interacts with the <strong data-start=\"873\" data-end=\"922\">intestinal wall, the immune system and the microbiome<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-195d0bd elementor-widget elementor-widget-text-editor\" data-id=\"195d0bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>We also wrote earlier that psilocybin also has anti-inflammatory properties in preclinical research and may even play a role in <strong data-start=\"1051\" data-end=\"1106\">slowing down aging and protecting DNA <\/strong>(research on cells in vitro and mice). If these effects are also present in humans and are combined with a healthy lifestyle, a powerful <strong data-start=\"1200\" data-end=\"1212\">synergy<\/strong> It&#039;s possible that mental, physical, and cellular processes reinforce each other. We use these scientific insights to further explore and reason about the impact of psilocybin on the microbiome. Use the buttons to read more about these mechanisms of action of psilocybin.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-70e6451 e-flex e-con-boxed e-con e-parent\" data-id=\"70e6451\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-40cb7db elementor-widget elementor-widget-button\" data-id=\"40cb7db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/psilocybin\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Psilocybin<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2cdbec5 elementor-widget elementor-widget-button\" data-id=\"2cdbec5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/new-mechanism-of-action-of-psilocybin-discovered-anti-inflammatory-in-the-brain\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Anti-inflammatory<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9f0709 elementor-widget elementor-widget-button\" data-id=\"d9f0709\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/psilocybin-against-dna-aging-protection-of-telomeres\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Anti-aging<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-36ce070 elementor-widget elementor-widget-button\" data-id=\"36ce070\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/psychedelic-therapy-combined-with-lifestyle-coaching\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Lifestyle + psilocybin<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-baf97d7 e-flex e-con-boxed e-con e-parent\" data-id=\"baf97d7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-61f73e4 elementor-widget elementor-widget-text-editor\" data-id=\"61f73e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>In this article, we&#039;ll explain the individual effects of psilocybin on the microbiome, inflammation, aging, and lifestyle. We&#039;ll also explain how these effects interact. We&#039;ll also discuss the <strong data-start=\"1513\" data-end=\"1544\">potential advantages and disadvantages<\/strong>, so that a complete picture emerges of what psilocybin can do in the body, especially the intestines.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-49d12ec e-flex e-con-boxed e-con e-parent\" data-id=\"49d12ec\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-862910b elementor-widget elementor-widget-heading\" data-id=\"862910b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"van-psilocybine-naar-psilocine-de-eerste-stop-is-de-darm\">From psilocybin to psilocin: the first stop is the gut<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d42279a e-flex e-con-boxed e-con e-parent\" data-id=\"d42279a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f302f89 e-con-full e-flex e-con e-child\" data-id=\"f302f89\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b3575a0 elementor-widget elementor-widget-text-editor\" data-id=\"b3575a0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"1699\" data-end=\"1896\"><strong data-start=\"2279\" data-end=\"2294\">Psilocybin<\/strong> is a natural compound found in certain mushrooms and truffles. It belongs to the group of <strong data-start=\"2409\" data-end=\"2424\">tryptamines<\/strong>, a family of molecules that resemble the body&#039;s own <strong data-start=\"2484\" data-end=\"2498\">tryptamine<\/strong> and <strong data-start=\"2502\" data-end=\"2516\">serotonin<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a691237 elementor-widget elementor-widget-text-editor\" data-id=\"a691237\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"2521\" data-end=\"2783\">When a person takes psilocybin, it is rapidly converted into psilocybin in the gastrointestinal tract and liver. <strong data-start=\"2623\" data-end=\"2636\">psilocin<\/strong>. This conversion occurs by enzymes that cleave off a phosphate group \u2013 hence psilocybin is also called the \u201cprodrug\u201d of psilocin.<\/p><ul><li data-start=\"2787\" data-end=\"2850\"><strong data-start=\"2787\" data-end=\"2802\">Psilocybin<\/strong> = inactive form (as found in truffles).<\/li><li data-start=\"2853\" data-end=\"2926\"><strong data-start=\"2853\" data-end=\"2866\">Psilocin<\/strong> = active form that affects the body and brain.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4571a53 e-con-full e-flex e-con e-child\" data-id=\"4571a53\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7e04770 elementor-widget elementor-widget-video\" data-id=\"7e04770\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/CFuqMf-kZx4&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;play_on_mobile&quot;:&quot;yes&quot;,&quot;mute&quot;:&quot;yes&quot;,&quot;loop&quot;:&quot;yes&quot;,&quot;yt_privacy&quot;:&quot;yes&quot;,&quot;lazy_load&quot;:&quot;yes&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8670051 e-flex e-con-boxed e-con e-parent\" data-id=\"8670051\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-807cd6b elementor-widget elementor-widget-text-editor\" data-id=\"807cd6b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"2928\" data-end=\"3226\">Psilocin can bind to serotonin due to its similarity <strong data-start=\"2989\" data-end=\"3013\">serotonin receptors<\/strong> in the nervous system. In the brain, the main <strong data-start=\"3063\" data-end=\"3082\">5-HT2A receptor<\/strong> important, because its activation is related to the psychedelic effects (visual changes, more intense emotions, sense of unity).<\/p><p data-start=\"3228\" data-end=\"3383\">But psilocin isn&#039;t confined to the brain: it&#039;s also found in the <strong data-start=\"3299\" data-end=\"3309\">intestines<\/strong> Correctly, it affects both host cells and microorganisms. Also compare the structures of serotonin, psilocybin, and psilocin and imagine how these substances can fit onto the same receptors due to their similar shapes.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cf3fa7e e-flex e-con-boxed e-con e-parent\" data-id=\"cf3fa7e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-262ed99 elementor-widget elementor-widget-image\" data-id=\"262ed99\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" decoding=\"async\" width=\"800\" height=\"155\" src=\"https:\/\/triptherapie.nl\/wp-content\/uploads\/2023\/06\/Psilocybine-psilocine-1024x198.png\" class=\"attachment-large size-large wp-image-43114\" alt=\"molecules serotonin, psilocybin and psilocin\" srcset=\"https:\/\/triptherapie.nl\/wp-content\/uploads\/2023\/06\/Psilocybine-psilocine-1024x198.png 1024w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2023\/06\/Psilocybine-psilocine-300x58.png 300w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2023\/06\/Psilocybine-psilocine-768x148.png 768w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2023\/06\/Psilocybine-psilocine.png 1052w\" sizes=\"(max-width: 800px) 100vw, 800px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-08aa201 e-flex e-con-boxed e-con e-parent\" data-id=\"08aa201\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ed91eb9 elementor-widget elementor-widget-heading\" data-id=\"ed91eb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"serotonine-in-de-darmen-meer-dan-een-neurotransmitter\">Serotonin in the gut: more than a neurotransmitter<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-395c98a e-flex e-con-boxed e-con e-parent\" data-id=\"395c98a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2cb9421 e-con-full e-flex e-con e-child\" data-id=\"2cb9421\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ae4e8fd elementor-widget elementor-widget-heading\" data-id=\"ae4e8fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\" id=\"wat-is-serotonine\">What is serotonin?<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a7d06dd elementor-widget elementor-widget-text-editor\" data-id=\"a7d06dd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"3483\" data-end=\"3803\"><strong data-start=\"3483\" data-end=\"3525\">Serotonin (5-hydroxytryptamine, 5-HT)<\/strong> is a neurotransmitter that plays a role in mood, sleep, and impulse control in the brain. But less well known is that <strong data-start=\"3649\" data-end=\"3732\">approximately 90% of all serotonin in our body is produced in the intestines<\/strong> by special cells in the intestinal wall, the <strong data-start=\"3773\" data-end=\"3800\">enterochromaffin cells<\/strong>.<\/p><p data-start=\"3805\" data-end=\"3858\">In the intestine, serotonin has several functions:<\/p><ul><li data-start=\"3861\" data-end=\"3958\">It regulates the <strong data-start=\"3878\" data-end=\"3894\">peristalsis<\/strong> (the squeezing movements that move food through the intestines).<\/li><li data-start=\"3961\" data-end=\"4028\">It affects the <strong data-start=\"3979\" data-end=\"4007\">sensitivity of the intestine<\/strong> (pain, pressure, stretch).<\/li><li data-start=\"4031\" data-end=\"4091\">It communicates with the <strong data-start=\"4056\" data-end=\"4073\">immune system<\/strong> in the intestinal wall.<\/li><li data-start=\"4092\" data-end=\"4157\"><p data-start=\"4094\" data-end=\"4157\">It works like <strong data-start=\"4108\" data-end=\"4137\">signaling substance for microbes<\/strong> in the intestinal lumen.<\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c26466 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"2c26466\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/serotonin-an-important-link-for-unhappiness\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Serotonin<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3f23a24 e-con-full e-flex e-con e-child\" data-id=\"3f23a24\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-91996b4 elementor-widget elementor-widget-video\" data-id=\"91996b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=tWg84GKZYbA&quot;,&quot;yt_privacy&quot;:&quot;yes&quot;,&quot;lazy_load&quot;:&quot;yes&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-22460db e-flex e-con-boxed e-con e-parent\" data-id=\"22460db\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-04481c7 elementor-widget elementor-widget-heading\" data-id=\"04481c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\" id=\"serotonine-als-communicatie-tussen-mens-en-microbe\">Serotonin as communication between humans and microbes<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-defa91c elementor-widget elementor-widget-text-editor\" data-id=\"defa91c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"4220\" data-end=\"4502\">Microorganisms in the intestine are not just passive inhabitants, but are in constant communication with our bodies. They can produce substances that affect humans (for example, fatty acids like butyrate), but they can also <strong data-start=\"4450\" data-end=\"4499\">recognize and respond to human substances<\/strong>.<\/p><p data-start=\"4504\" data-end=\"4759\">Serotonin is one such signaling substance. Some bacteria have specific proteins that allow them to detect serotonin and adjust their behavior accordingly. Psilocin, which closely resembles serotonin, likely exerts its effects via the same mechanisms.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ec3e82a e-flex e-con-boxed e-con e-parent\" data-id=\"ec3e82a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-45ae184 elementor-widget elementor-widget-heading\" data-id=\"45ae184\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"welke-micro-organismen-reageren-op-serotonine-en-mogelijk-psilocine\">Which microorganisms respond to serotonin (and possibly psilocin)?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb7c353 elementor-widget elementor-widget-text-editor\" data-id=\"eb7c353\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>There are two known ways in which microorganisms in the microbiome can measure and respond to the levels of serotonergic substances such as serotonin and the similar substance psilocin: the CpxA\/CpxR system in bacteria and the LasR system.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dd0110c e-flex e-con-boxed e-con e-parent\" data-id=\"dd0110c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-8f16bb5 e-con-full e-flex e-con e-child\" data-id=\"8f16bb5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c903580 elementor-widget elementor-widget-heading\" data-id=\"c903580\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\" id=\"het-cpxa-cpxr-systeem\">The CpxA\/CpxR system<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24821d2 elementor-widget elementor-widget-text-editor\" data-id=\"24821d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>It <strong data-start=\"278\" data-end=\"299\">CpxA\/CpxR system<\/strong> is a so-called <em data-start=\"317\" data-end=\"341\">two-component system<\/em> which is common in Gram-negative bacteria such as <em data-start=\"395\" data-end=\"413\">Escherichia coli<\/em> and <em data-start=\"417\" data-end=\"429\">Salmonella<\/em>. CpxA is a membrane-bound sensor that detects changes in the environment. When serotonin, or possibly psilocin (further research needed), binds to CpxA, signal transmission to the regulator CpxR changes. This changes genes involved in <strong data-start=\"659\" data-end=\"673\">virulence<\/strong> (the pathogenic potential of a bacterium) is suppressed. The result is that the bacterium is less able to adhere, produces fewer toxins, and behaves less aggressively in the intestine. In this way, an increased presence of serotonergic substances can <strong data-start=\"938\" data-end=\"960\">protective effect<\/strong> have against excessive bacterial load.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bf87dad elementor-widget elementor-widget-text-editor\" data-id=\"bf87dad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Microorganisms involved:<\/strong><\/p><ol><li><strong>Escherichia coli<\/strong>The most common intestinal resident: usually harmless, but some strains cause diarrhea, urinary tract infections, or even blood poisoning. Through CpxA\/CpxR, they respond to serotonin\/psilocin with less virulence.<\/li><li><strong>Salmonella enterica: <\/strong>Responsible for food poisoning and typhoid. Through CpxA, serotonin can inhibit the activity of so-called virulence islands, thus hindering the bacteria&#039;s ability to spread.<\/li><li><strong>Shigella spp<\/strong>: Causes bloody diarrhea (shigellosis). Although less well-researched, serotonin is also expected to inhibit virulence here.<\/li><li><strong>Yersinia spp:<\/strong>\u00a0Known from the plague (Y. pestis), but also intestinal infections (Y. enterocolitica). The CpxA system is influenced by serotonin, likely with inhibitory effects on pathogenic behavior.<\/li><li><strong>Klebsiella pneumoniae<\/strong>Normally present in the intestines, but in weakened individuals it can cause pneumonia or sepsis. CpxA\/CpxR helps this bacterium process stress signals; serotonin reduces virulence.<\/li><li><strong>Enterobacter spp: <\/strong>Common intestinal commensals that are usually harmless. They can, however, cause infections in weakened immune systems. Here too, serotonin likely has a mitigating effect on virulence.<\/li><li><strong>Citrobacter spp: <\/strong>Similar to Enterobacter: present in the intestines, sometimes causing opportunistic infections. CpxA makes them sensitive to serotonin, making them less aggressive.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-938638c e-con-full e-flex e-con e-child\" data-id=\"938638c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f00f307 elementor-widget elementor-widget-heading\" data-id=\"f00f307\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\" id=\"het-lasr-systeem\">The LasR system<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-822973a elementor-widget elementor-widget-text-editor\" data-id=\"822973a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The LasR system is mainly used by <em data-start=\"182\" data-end=\"206\">Pseudomonas aeruginosa<\/em>, an opportunistic bacterium. LasR is part of a quorum-sensing mechanism: a way in which bacteria communicate with each other to adjust their behavior when they are present in large numbers. Normally, LasR binds to auto-inducer molecules that bacteria produce themselves, but research shows that serotonin disrupts this system in <em data-start=\"543\" data-end=\"558\">P. aeruginosa<\/em> can activate. This leads to an increase in virulence: the bacteria form more biofilm (a protective slime layer), produce more harmful enzymes, and become more aggressive. This has not yet been directly investigated for psilocin, which closely resembles serotonin, but it is plausible.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d0c020 elementor-widget elementor-widget-text-editor\" data-id=\"9d0c020\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Microorganisms involved:<\/strong><\/p><p data-start=\"843\" data-end=\"876\">\u00a0<\/p><ol><li data-start=\"880\" data-end=\"1347\"><strong data-start=\"880\" data-end=\"906\">Pseudomonas aeruginosa<\/strong>: An opportunistic pathogen found in the intestines, skin, and lungs, it is particularly dangerous in weakened individuals. Through the LasR system, this bacterium responds to serotonin by increasing its virulence. It forms more biofilm and releases more harmful enzymes, making infections more severe and difficult to combat. A similar effect is suspected for psilocin, but this remains to be confirmed.<\/li><li data-start=\"1350\" data-end=\"1627\"><strong data-start=\"1350\" data-end=\"1377\">Pseudomonas fluorescens<\/strong>Usually a relatively harmless organism, but can become opportunistically pathogenic under certain circumstances. This species possesses LasR homologs and could theoretically react similarly, but this has not yet been convincingly demonstrated.<\/li><li data-start=\"1630\" data-end=\"1942\"><strong data-start=\"1630\" data-end=\"1662\">Burkholderia cepacia complex<\/strong>Known as a cause of persistent infections in people with cystic fibrosis. This group of bacteria has several quorum-sensing regulators related to LasR. It is conceivable that serotonin or psilocin plays a role in this, but firm research results are lacking.<\/li><li data-start=\"1945\" data-end=\"2230\"><strong data-start=\"1945\" data-end=\"1972\">Acinetobacter baumannii<\/strong>A major cause of hospital infections, particularly in the respiratory tract, urinary tract, and wounds. This bacterium also has LasR-like regulators, but whether serotonin or psilocin actually increases virulence in this case has not yet been convincingly proven.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-982c9d3 e-flex e-con-boxed e-con e-parent\" data-id=\"982c9d3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7a0cd76 elementor-widget elementor-widget-heading\" data-id=\"7a0cd76\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"netto-effect-op-de-microbioom\">Net effect on the microbiome<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a86883 elementor-widget elementor-widget-text-editor\" data-id=\"7a86883\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<blockquote><p data-start=\"610\" data-end=\"1336\"><em>This piece about the positive effect of psilocybin on the microbiome is our hypothesis, based on extrapolation from studies of psilocybin on human cells and animals. For now, this remains a hypothesis because the direct effects of psilocybin on the composition of the human microbiome have not yet been convincingly demonstrated by scientific studies.<\/em><\/p><\/blockquote><p data-start=\"610\" data-end=\"1336\">On the one hand, psilocin can be a <strong data-start=\"644\" data-end=\"667\">health benefit<\/strong> mean. In bacteria that use the <strong data-start=\"718\" data-end=\"739\">CpxA\/CpxR system<\/strong>, such as <em data-start=\"747\" data-end=\"765\">Escherichia coli<\/em>, <em data-start=\"767\" data-end=\"779\">Salmonella<\/em> and <em data-start=\"783\" data-end=\"806\">Klebsiella pneumoniae<\/em>, the binding of serotonin or psilocin leads to a decrease in <strong data-start=\"878\" data-end=\"892\">virulence<\/strong>. This means that these bacteria adhere less effectively to the intestinal wall, produce fewer toxins, and behave more calmly. This can be positive for the host, as the burden on the immune system is reduced and the risk of inflammation is reduced. Yeasts such as <em data-start=\"1168\" data-end=\"1186\">Candida albicans<\/em> react favourably: serotonin and probably also psilocin inhibit the transition to the aggressive hyphal form and thus limit the risk of overgrowth.<\/p><p data-start=\"1338\" data-end=\"1955\">On the other hand, psilocin can also be a <strong data-start=\"1379\" data-end=\"1399\">unfavorable effect<\/strong> have. Bacteria that use the <strong data-start=\"1443\" data-end=\"1459\">LasR system<\/strong>, such as <em data-start=\"1467\" data-end=\"1491\">Pseudomonas aeruginosa<\/em>, may actually respond with an increase in virulence. Under the influence of serotonin and psilocin, they form more biofilm and produce harmful enzymes. This makes them more difficult to combat and can lead to increased inflammation and symptoms, especially in people with weakened immune systems or a disrupted microbiome. Other bacteria with LasR-like systems, such as <em data-start=\"1866\" data-end=\"1888\">Burkholderia cepacia<\/em> and <em data-start=\"1892\" data-end=\"1917\">Acinetobacter baumannii<\/em>, show similar responses.<\/p><p data-start=\"1957\" data-end=\"2340\">It is therefore clear that psilocin is not unequivocally &quot;good&quot; or &quot;bad&quot; for the intestinal flora. The effect depends on the <strong data-start=\"2078\" data-end=\"2108\">present microorganisms<\/strong> and the balance of the microbiome. In healthy people with stable gut flora, the beneficial effects may predominate, while in people with many opportunistic bacteria, the unfavorable effects may be more noticeable.<\/p><p data-start=\"2342\" data-end=\"2826\">However, this also needs to be put into perspective. A psilocybin experience lasts on average <strong data-start=\"2439\" data-end=\"2450\">six o&#039;clock<\/strong>. This means that the exposure of microbes to psilocin is relatively short. For most microorganisms, the impact will be temporary and will not permanently change the composition of the intestinal flora. At most, there may be some <strong data-start=\"2717\" data-end=\"2755\">increased or decreased activity<\/strong>, which then decreases again as the drug leaves the body.<\/p><p data-start=\"2828\" data-end=\"3295\">In summary, psilocybin could theoretically contribute to a reduction in the number of microbes <strong data-start=\"2895\" data-end=\"2923\">less pathogenic behavior<\/strong>, which is positive for health, while for other microbes it is a <strong data-start=\"3003\" data-end=\"3025\">stimulating effect<\/strong> may have a temporary detrimental effect. Given the short duration of a session, the impact on the microbiome is likely limited. Further research should clarify the exact influence of psilocin on the<strong> LasR system<\/strong> and <strong data-start=\"718\" data-end=\"739\">CpxA\/CpxR system<\/strong>.<strong>\u00a0<\/strong>We hope and expect that the effect on the CpxA\/CpxR system is greater than on the LasR system, as this would better explain the positive effects of psilocybin on lasting mood improvements.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9117700 e-flex e-con-boxed e-con e-parent\" data-id=\"9117700\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ccdb592 elementor-widget elementor-widget-heading\" data-id=\"ccdb592\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"psilocybine-microbioom-ontsteking-veroudering-en-leefstijl-een-verbonden-geheel\">Psilocybin, microbiome, inflammation, aging and lifestyle: one connected whole<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1feca98 elementor-widget elementor-widget-text-editor\" data-id=\"1feca98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"390\" data-end=\"745\">When we compare the various effects of psilocybin, a clear pattern emerges: the microbiome is the linchpin that connects everything. Psilocybin&#039;s influence on gut microbes impacts inflammation, cell aging, and even the ability to make and maintain healthy lifestyle choices.<\/p><p data-start=\"747\" data-end=\"1459\">One of the most important effects in the intestines is that psilocybin is absorbed by many microorganisms through the <strong data-start=\"847\" data-end=\"868\">CpxA\/CpxR system<\/strong> the <strong data-start=\"872\" data-end=\"895\">virulence decreases<\/strong>.This literally gives the immune system a rest and ensures a <strong data-start=\"1111\" data-end=\"1137\">lower ignition pressure<\/strong>.<\/p><p data-start=\"1461\" data-end=\"2124\">Less inflammation in the intestines translates into a <strong data-start=\"1513\" data-end=\"1545\">healthier microbiome environment<\/strong>. A calmer gut flora produces more protective substances such as short-chain fatty acids, which in turn strengthen the intestinal wall and further inhibit inflammation. This cascade affects the rest of the body: lower inflammation levels mean less damage to cells and DNA. Chronic inflammation is, after all, a significant accelerator of aging, partly because it causes telomeres, the protective caps on our DNA, to shorten more quickly. By inhibiting inflammation and reducing cellular stress, psilocybin can indirectly contribute to <strong data-start=\"2098\" data-end=\"2121\">healthy aging<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc15899 elementor-widget elementor-widget-image\" data-id=\"bc15899\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"1667\" height=\"794\" src=\"https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome.avif\" class=\"attachment-full size-full wp-image-52998\" alt=\"Research on psilocybin on the intestines\" srcset=\"https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome.avif 1667w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome-300x143.png 300w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome-1024x488.png 1024w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome-768x366.png 768w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome-1536x732.png 1536w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome-18x9.png 18w\" sizes=\"(max-width: 1667px) 100vw, 1667px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-84e4020 elementor-widget elementor-widget-text-editor\" data-id=\"84e4020\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"2126\" data-end=\"2713\">This creates a synergistic whole: the microbiome influences inflammation, inflammation influences aging, and psilocybin (psilocin) acts on all these levels simultaneously. The psychological effects of psilocybin also play a role. During a session, people often gain new insights and greater motivation to live healthier. This behavioral change has a direct impact on the microbiome: a higher-fiber diet, more exercise, better sleep, and less stress strengthen the gut flora, further supporting the anti-inflammatory and anti-aging effects of psilocybin.<\/p><p data-start=\"2715\" data-end=\"3227\">Thus, psilocybin forms a <strong data-start=\"2740\" data-end=\"2772\">bridge between mind and body<\/strong>. In the gut, it influences microbes and inflammation levels; in the brain, it creates space for new patterns and behavioral choices. Both pathways reinforce each other via the microbiota\u2013gut\u2013brain axis. Ultimately, a vicious cycle of positive change emerges: a calmer microbiome leads to less inflammation, which slows cell aging and paves the way for sustainable lifestyle improvements, which in turn further strengthen the microbiome.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f70cf9 e-flex e-con-boxed e-con e-parent\" data-id=\"7f70cf9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8be2fbe elementor-widget elementor-widget-heading\" data-id=\"8be2fbe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"conclusie-en-bronnen\">Conclusion and sources<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b4eecc0 e-flex e-con-boxed e-con e-parent\" data-id=\"b4eecc0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0e1ae24 e-con-full e-flex e-con e-child\" data-id=\"0e1ae24\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-da61d5f elementor-widget elementor-widget-text-editor\" data-id=\"da61d5f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"2715\" data-end=\"3227\">The potential positive effects of psilocybin on the microbiome don&#039;t occur in isolation. They form the starting point of a chain reaction that affects inflammation, aging, and behavior. It is this holistic connection that explains why psilocybin can not only bring mental relief but could also have tangible physical health benefits.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f13ec2f elementor-widget elementor-widget-text-editor\" data-id=\"f13ec2f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"2715\" data-end=\"3227\">At the same time, it is important to emphasize that many of these findings so far have mainly come from <strong data-start=\"602\" data-end=\"627\">preclinical research<\/strong> (cells and mice) come. Large-scale and long-term <strong data-start=\"680\" data-end=\"704\">human research<\/strong> is still needed to confirm the extent to which psilocybin actually has anti-inflammatory, anti-aging or microbiome-modulating effects.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4b9f87e e-con-full e-flex e-con e-child\" data-id=\"4b9f87e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c3f17cd elementor-widget elementor-widget-image\" data-id=\"c3f17cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"300\" height=\"298\" src=\"https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilocybine-efffect-300x298.png\" class=\"attachment-medium size-medium wp-image-53003\" alt=\"Physical effects of psilocybin\" srcset=\"https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilocybine-efffect-300x298.png 300w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilocybine-efffect-150x150.png 150w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilocybine-efffect-768x764.png 768w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilocybine-efffect-12x12.png 12w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilocybine-efffect.avif 901w\" sizes=\"(max-width: 300px) 100vw, 300px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aac3fb8 e-flex e-con-boxed e-con e-parent\" data-id=\"aac3fb8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ba9c0a elementor-widget elementor-widget-text-editor\" data-id=\"9ba9c0a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"848\" data-end=\"1200\">What is already clear is that psilocybin forms a powerful bridge between mind and body. It can provide insights and motivation to live healthier, and precisely these lifestyle changes have a proven positive effect on gut flora, inflammation, and aging. This creates a synergy between psychological, biological, and lifestyle processes.<\/p><p data-start=\"1202\" data-end=\"1499\">This blog post is based on our own articles and insights, supplemented with scientific sources. The buttons below will guide you through the physical effects of psilocybin, the research we cite, and how to register for psilocybin therapy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-40a478c e-flex e-con-boxed e-con e-parent\" data-id=\"40a478c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-568f96f elementor-widget elementor-widget-button\" data-id=\"568f96f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9791138\/\" target=\"_blank\" rel=\"noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Source research<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e50ff28 elementor-widget elementor-widget-button\" data-id=\"e50ff28\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/psilocybin-therapy\/#psilocybine-sessies-bij-triptherapie\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Psilocybin therapy<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Psilocybin not only induces a trip, but can even affect the bacteria and fungi in your gut! This way, your microbiome also gets tripped.<\/p>","protected":false},"author":1,"featured_media":53022,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[1274,1275,1276,11],"class_list":["post-52956","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","tag-darmen","tag-microben","tag-microbioom","tag-psilocybine"],"_links":{"self":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/posts\/52956","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/comments?post=52956"}],"version-history":[{"count":0,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/posts\/52956\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/media\/53022"}],"wp:attachment":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/media?parent=52956"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/categories?post=52956"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/tags?post=52956"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}