{"id":52956,"date":"2025-08-29T20:03:46","date_gmt":"2025-08-29T18:03:46","guid":{"rendered":"https:\/\/triptherapie.nl\/?p=52956"},"modified":"2025-08-29T20:03:59","modified_gmt":"2025-08-29T18:03:59","slug":"how-psilocybin-affects-the-microbes-in-the-gut","status":"publish","type":"post","link":"https:\/\/triptherapie.nl\/en\/hoe-psilocybine-de-microben-in-de-darmen-beinvloedt\/","title":{"rendered":"How psilocybin affects the microbes in the gut"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"52956\" class=\"elementor elementor-52956\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-219c143 e-flex e-con-boxed e-con e-parent\" data-id=\"219c143\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-aced939 elementor-widget elementor-widget-heading\" data-id=\"aced939\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"psilocybine-is-meer-dan-een-geestverruimend-middel\">Psilocybin is more than a psychedelic drug<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-45a9181 elementor-widget elementor-widget-text-editor\" data-id=\"45a9181\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Psilocybin is primarily known for its profound influence on consciousness, emotions, and spirituality. However, the effects of psilocybin do not only take place in the brain. As soon as psilocybin is ingested, it first enters the intestines, where it is converted into <strong data-start=\"734\" data-end=\"747\">psilocybin<\/strong>. This is the active substance that affects not only serotonin receptors in the brain, but also interacts with the <strong data-start=\"873\" data-end=\"922\">intestinal wall, the immune system and the microbiome<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-195d0bd elementor-widget elementor-widget-text-editor\" data-id=\"195d0bd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>We also wrote earlier that psilocybin also acts as an anti-inflammatory in preclinical research and may even play a role in <strong data-start=\"1051\" data-end=\"1106\">Slows down aging and protects DNA <\/strong>(in vitro cell studies and in mice). When these effects are also present in humans and combined with a healthy lifestyle, a powerful <strong data-start=\"1200\" data-end=\"1212\">synergy<\/strong> It is possible that mental, physical, and cellular processes mutually reinforce each other. We therefore use this scientific insight to further explore and understand the impact of psilocybin on the microbiome. Use the buttons to read more about these mechanisms of action of psilocybin.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-70e6451 e-flex e-con-boxed e-con e-parent\" data-id=\"70e6451\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-40cb7db elementor-widget elementor-widget-button\" data-id=\"40cb7db\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/psilocybin-2\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Psilocybin<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2cdbec5 elementor-widget elementor-widget-button\" data-id=\"2cdbec5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/new-mechanism-of-action-of-psilocybin-discovered-as-an-anti-inflammatory-agent-in-the-brain-2\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Anti-inflammatory effect<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d9f0709 elementor-widget elementor-widget-button\" data-id=\"d9f0709\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/psilocybin-against-dna-aging-protection-of-telomeres\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Anti-aging<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-36ce070 elementor-widget elementor-widget-button\" data-id=\"36ce070\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/psychedelic-therapy-combined-with-lifestyle-coaching\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Lifestyle + psilocybin<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-baf97d7 e-flex e-con-boxed e-con e-parent\" data-id=\"baf97d7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-61f73e4 elementor-widget elementor-widget-text-editor\" data-id=\"61f73e4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>In this article, we explain what the individual effects of psilocybin are on the microbiome, inflammatory processes, aging, and lifestyle. We also explain how these effects interact with each other. We also discuss <strong data-start=\"1513\" data-end=\"1544\">Potential advantages and disadvantages<\/strong>, so that a complete picture emerges of what psilocybin can do in the body, especially the intestines.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-49d12ec e-flex e-con-boxed e-con e-parent\" data-id=\"49d12ec\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-862910b elementor-widget elementor-widget-heading\" data-id=\"862910b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"van-psilocybine-naar-psilocine-de-eerste-stop-is-de-darm\">From psilocybin to psilocine: the first stop is the gut<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d42279a e-flex e-con-boxed e-con e-parent\" data-id=\"d42279a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f302f89 e-con-full e-flex e-con e-child\" data-id=\"f302f89\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b3575a0 elementor-widget elementor-widget-text-editor\" data-id=\"b3575a0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"1699\" data-end=\"1896\"><strong data-start=\"2279\" data-end=\"2294\">Psilocybin<\/strong> is a natural compound that is found in certain mushrooms and truffles. It belongs to the group of <strong data-start=\"2409\" data-end=\"2424\">triptamines<\/strong>, a family of molecules that resemble those found in the body <strong data-start=\"2484\" data-end=\"2498\">Tryptamine<\/strong> en <strong data-start=\"2502\" data-end=\"2516\">serotonin<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a691237 elementor-widget elementor-widget-text-editor\" data-id=\"a691237\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"2521\" data-end=\"2783\">When someone takes psilocybin, it is quickly converted in the gastrointestinal tract and in the liver into <strong data-start=\"2623\" data-end=\"2636\">psilocybin<\/strong>. This conversion is carried out by enzymes that split off a phosphate group \u2013 hence psilocybin is also called the \u201cprodrug\u201d of psilocin.<\/p><ul><li data-start=\"2787\" data-end=\"2850\"><strong data-start=\"2787\" data-end=\"2802\">Psilocybin<\/strong> = inactive form (as in the case of truffles).<\/li><li data-start=\"2853\" data-end=\"2926\"><strong data-start=\"2853\" data-end=\"2866\">Psilocybin<\/strong> = active form that acts on the body and the brain.<\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4571a53 e-con-full e-flex e-con e-child\" data-id=\"4571a53\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7e04770 elementor-widget elementor-widget-video\" data-id=\"7e04770\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/youtu.be\\\/CFuqMf-kZx4&quot;,&quot;autoplay&quot;:&quot;yes&quot;,&quot;play_on_mobile&quot;:&quot;yes&quot;,&quot;mute&quot;:&quot;yes&quot;,&quot;loop&quot;:&quot;yes&quot;,&quot;yt_privacy&quot;:&quot;yes&quot;,&quot;lazy_load&quot;:&quot;yes&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8670051 e-flex e-con-boxed e-con e-parent\" data-id=\"8670051\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-807cd6b elementor-widget elementor-widget-text-editor\" data-id=\"807cd6b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"2928\" data-end=\"3226\">Psilocybin can bind to serotonin due to its similarity to it. <strong data-start=\"2989\" data-end=\"3013\">serotonin receptors<\/strong> in the nervous system. In the brain, especially the <strong data-start=\"3063\" data-end=\"3082\">5-HT2A receptor<\/strong> important, because activation thereof is associated with the psychedelic effects (visual changes, heightened emotions, a sense of unity).<\/p><p data-start=\"3228\" data-end=\"3383\">But psilocybin doesn't remain confined to the brain: it also enters the <strong data-start=\"3299\" data-end=\"3309\">intestines<\/strong> Rightly so, where it affects both host cells and microorganisms. Also compare the structure between serotonin, psilocybin and psilocin and imagine how these substances can fit into the same receptors due to the similar shape.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cf3fa7e e-flex e-con-boxed e-con e-parent\" data-id=\"cf3fa7e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-262ed99 elementor-widget elementor-widget-image\" data-id=\"262ed99\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"800\" height=\"155\" src=\"https:\/\/triptherapie.nl\/wp-content\/uploads\/2023\/06\/Psilocybine-psilocine-1024x198.png\" class=\"attachment-large size-large wp-image-43114\" alt=\"serotonin molecules, psilocybin and psilocine\" srcset=\"https:\/\/triptherapie.nl\/wp-content\/uploads\/2023\/06\/Psilocybine-psilocine-1024x198.png 1024w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2023\/06\/Psilocybine-psilocine-300x58.png 300w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2023\/06\/Psilocybine-psilocine-768x148.png 768w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2023\/06\/Psilocybine-psilocine.png 1052w\" sizes=\"auto, (max-width: 800px) 100vw, 800px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-08aa201 e-flex e-con-boxed e-con e-parent\" data-id=\"08aa201\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ed91eb9 elementor-widget elementor-widget-heading\" data-id=\"ed91eb9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"serotonine-in-de-darmen-meer-dan-een-neurotransmitter\">Serotonin in the intestines: more than just a neurotransmitter<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-395c98a e-flex e-con-boxed e-con e-parent\" data-id=\"395c98a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-2cb9421 e-con-full e-flex e-con e-child\" data-id=\"2cb9421\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ae4e8fd elementor-widget elementor-widget-heading\" data-id=\"ae4e8fd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\" id=\"wat-is-serotonine\">What is serotonin?<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a7d06dd elementor-widget elementor-widget-text-editor\" data-id=\"a7d06dd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"3483\" data-end=\"3803\"><strong data-start=\"3483\" data-end=\"3525\">Serotonin (5-hydroxytryptamine, 5-HT)<\/strong> is a neurotransmitter that plays a role in the brain when it comes to mood, sleep, and impulse control. But what is less known is that <strong data-start=\"3649\" data-end=\"3732\">about 90% of all serotonin in our body is produced in the intestines<\/strong> through special cells in the intestinal wall, the <strong data-start=\"3773\" data-end=\"3800\">Enterochromaffin cells<\/strong>.<\/p><p data-start=\"3805\" data-end=\"3858\">In the gut, serotonin has several functions:<\/p><ul><li data-start=\"3861\" data-end=\"3958\">It regulates the <strong data-start=\"3878\" data-end=\"3894\">peristaltic<\/strong> (the squeezing movements that move food through the intestines).<\/li><li data-start=\"3961\" data-end=\"4028\">It affects the <strong data-start=\"3979\" data-end=\"4007\">sensitivity of the intestine<\/strong> (pain, pressure, stretching).<\/li><li data-start=\"4031\" data-end=\"4091\">It communicates with the <strong data-start=\"4056\" data-end=\"4073\">immune system<\/strong> in the intestinal wall.<\/li><li data-start=\"4092\" data-end=\"4157\"><p data-start=\"4094\" data-end=\"4157\">It works like <strong data-start=\"4108\" data-end=\"4137\">signal substance for microbes<\/strong> in the intestinal lumen.<\/p><\/li><\/ul>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c26466 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"2c26466\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/serotonin-is-an-important-link-for-unhappiness\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Serotonin<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3f23a24 e-con-full e-flex e-con e-child\" data-id=\"3f23a24\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-91996b4 elementor-widget elementor-widget-video\" data-id=\"91996b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=tWg84GKZYbA&quot;,&quot;yt_privacy&quot;:&quot;yes&quot;,&quot;lazy_load&quot;:&quot;yes&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-22460db e-flex e-con-boxed e-con e-parent\" data-id=\"22460db\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-04481c7 elementor-widget elementor-widget-heading\" data-id=\"04481c7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\" id=\"serotonine-als-communicatie-tussen-mens-en-microbe\">Serotonin as a communication between humans and microbes<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-defa91c elementor-widget elementor-widget-text-editor\" data-id=\"defa91c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"4220\" data-end=\"4502\">Microorganisms in the gut are not only passive residents, but are in constant communication with our body. They can produce substances that affect humans (for example, fatty acids such as butyrate), but they can also <strong data-start=\"4450\" data-end=\"4499\">recognize and respond to human substances<\/strong>.<\/p><p data-start=\"4504\" data-end=\"4759\">Serotonin is one such signaling molecule. Some bacteria have specific proteins that allow them to detect serotonin and adapt their behavior accordingly. Psilocin, which closely resembles serotonin, is likely to exert its effects via the same mechanisms.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ec3e82a e-flex e-con-boxed e-con e-parent\" data-id=\"ec3e82a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-45ae184 elementor-widget elementor-widget-heading\" data-id=\"45ae184\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"welke-micro-organismen-reageren-op-serotonine-en-mogelijk-psilocine\">Which microorganisms respond to serotonin (and possibly psilocin)?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb7c353 elementor-widget elementor-widget-text-editor\" data-id=\"eb7c353\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>There are two known ways in which microorganisms in the microbiome can measure and respond to the amount of serotonergic substances such as serotonin and the similar substance psilocin. This occurs via the CpxA\/CpxR system in bacteria and via the LasR system.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-dd0110c e-flex e-con-boxed e-con e-parent\" data-id=\"dd0110c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-8f16bb5 e-con-full e-flex e-con e-child\" data-id=\"8f16bb5\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c903580 elementor-widget elementor-widget-heading\" data-id=\"c903580\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\" id=\"het-cpxa-cpxr-systeem\">The CpxA\/CpxR system<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-24821d2 elementor-widget elementor-widget-text-editor\" data-id=\"24821d2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>It <strong data-start=\"278\" data-end=\"299\">CpxA\/CpxR system<\/strong> is a so-called <em data-start=\"317\" data-end=\"341\">two-component system<\/em> which is common in Gram-negative bacteria such as <em data-start=\"395\" data-end=\"413\">Escherichia coli<\/em> en <em data-start=\"417\" data-end=\"429\">Salmonella<\/em>. CpxA is a membrane-bound sensor that detects changes in the environment. When serotonin or possibly psilocin (more research needed) binds to CpxA, the signal transmission to the regulator CpxR changes. This causes genes involved in <strong data-start=\"659\" data-end=\"673\">virulence<\/strong> (the harmful effect of a bacterium) is suppressed. The result is that the bacterium is less able to attach itself, produces less toxins and behaves less aggressively in the gut. In this way, an increased presence of serotonergic substances can <strong data-start=\"938\" data-end=\"960\">protective effect<\/strong> have an excessive bacterial load.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bf87dad elementor-widget elementor-widget-text-editor\" data-id=\"bf87dad\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contaminated microorganisms:<\/strong><\/p><ol><li><strong>Escherichia coli<\/strong>The most well-known intestinal parasites: usually harmless, but some strains cause diarrhea, urinary infections or even blood poisoning. Through CpxA\/CpxR they react to serotonin\/psilocin with lower virulence.<\/li><li><strong>Salmonella enterica: <\/strong>Responsible for food poisoning and typhoid. Through CpxA, serotonin can inhibit the activity of so-called virulence islands, which makes it less likely that the bacteria can spread.<\/li><li><strong>Shigella spp<\/strong>Causes bloody diarrhea (shigellosis). Although less well studied, it is expected that serotonin also inhibits virulence in this case.<\/li><li><strong>Yersinia spp:<\/strong>\u00a0Known from plague (Y. pestis), but also intestinal infections (Y. enterocolitica). The CpxA system is influenced by serotonin, probably with inhibitory effects on disease-causing behavior.<\/li><li><strong>Klebsiella pneumoniae<\/strong>Normally present in the intestine, but in weakened people it can cause pneumonia or sepsis. CpxA\/CpxR helps this bacterium process stress signals; serotonin reduces virulence.<\/li><li><strong>Enterobacter spp: <\/strong>Common intestinal commensals that are usually harmless. In cases of weak immune systems, they can cause infections. Here too, serotonin likely plays a role in suppressing virulence.<\/li><li><strong>Citrobacter spp: <\/strong>Similar to Enterobacter: present in the intestine, sometimes causing opportunistic infections. CpxA makes them susceptible to serotonin, making them less aggressive.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-938638c e-con-full e-flex e-con e-child\" data-id=\"938638c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f00f307 elementor-widget elementor-widget-heading\" data-id=\"f00f307\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h3 class=\"elementor-heading-title elementor-size-default\" id=\"het-lasr-systeem\">The LasR system<\/h3>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-822973a elementor-widget elementor-widget-text-editor\" data-id=\"822973a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The LasR system is mainly used by <em data-start=\"182\" data-end=\"206\">Pseudomonas aeruginosa<\/em>, LasR is part of a quorum-sensing mechanism: a way in which bacteria communicate with each other to adjust their behavior as soon as they are present in large numbers. Normally, LasR binds to auto-inducer molecules that bacteria themselves produce, but research shows that serotonin disrupts this system in <em data-start=\"543\" data-end=\"558\">P. aeruginosa<\/em> can be activated. This leads to an increase in virulence: the bacteria produce more biofilm (a protective mucous layer), produce more harmful enzymes and become more aggressive. For psilocybin, which is very similar to serotonin, this has not yet been directly investigated but is plausible.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9d0c020 elementor-widget elementor-widget-text-editor\" data-id=\"9d0c020\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p><strong>Contaminated microorganisms:<\/strong><\/p><p data-start=\"843\" data-end=\"876\">\u00a0<\/p><ol><li data-start=\"880\" data-end=\"1347\"><strong data-start=\"880\" data-end=\"906\">Pseudomonas aeruginosa<\/strong>: An opportunistic pathogen that occurs in the gut, skin, and lungs and is especially dangerous in weakened people. Through the LasR system, this bacterium reacts to serotonin with an increase in virulence. More biofilm is formed and more harmful enzymes are released, making infections more serious and harder to control. A similar effect is suspected for psilocybin, but this needs to be confirmed.<\/li><li data-start=\"1350\" data-end=\"1627\"><strong data-start=\"1350\" data-end=\"1377\">Pseudomonas fluorescens<\/strong>Usually a relatively harmless organism, but in certain circumstances it can become an opportunistic pathogen. This species possesses LasR homologs and could theoretically react similarly, but this has not yet been convincingly demonstrated.<\/li><li data-start=\"1630\" data-end=\"1942\"><strong data-start=\"1630\" data-end=\"1662\">Burkholderia cepacia complex<\/strong>: Known to cause persistent infections in people with leprosy. This group of bacteria has several quorum-sensing regulators that are related to LasR. It is conceivable that serotonin or psilocin has an effect on this, but there are no hard research results available.<\/li><li data-start=\"1945\" data-end=\"2230\"><strong data-start=\"1945\" data-end=\"1972\">Acinetobacter baumannii<\/strong>: An important cause of hospital infections, especially in the respiratory tract, urinary tract and wounds. This bacterium also has LasR-like regulators, but whether serotonin or psilocin actually increases virulence is not yet convincingly proven.<\/li><\/ol>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-982c9d3 e-flex e-con-boxed e-con e-parent\" data-id=\"982c9d3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7a0cd76 elementor-widget elementor-widget-heading\" data-id=\"7a0cd76\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"netto-effect-op-de-microbioom\">Net effect on the microbiome<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a86883 elementor-widget elementor-widget-text-editor\" data-id=\"7a86883\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<blockquote><p data-start=\"610\" data-end=\"1336\"><em>This piece about the beneficial effect of psilocybin on the microbiome is a hypothesis from our perspective, based on extrapolation from studies on psilocybin in human cells and animals. This remains a hypothesis for the time being because the direct effects of psilocybin on the composition of the human microbiome have not yet been convincingly demonstrated through scientific research.<\/em><\/p><\/blockquote><p data-start=\"610\" data-end=\"1336\">On the one hand, psilocybin can be <strong data-start=\"644\" data-end=\"667\">health benefit<\/strong> mean. In bacteria that use the <strong data-start=\"718\" data-end=\"739\">CpxA\/CpxR system<\/strong>, as <em data-start=\"747\" data-end=\"765\">Escherichia coli<\/em>, <em data-start=\"767\" data-end=\"779\">Salmonella<\/em> en <em data-start=\"783\" data-end=\"806\">Klebsiella pneumoniae<\/em>, the binding of serotonin or psilocin leads to a reduction in the <strong data-start=\"878\" data-end=\"892\">virulence<\/strong>. This means that these bacteria attach less well to the intestinal wall, produce fewer toxins, and behave more calmly. This can be beneficial for the host, as the strain on the immune system decreases and the risk of inflammation is reduced. Yeasts such as <em data-start=\"1168\" data-end=\"1186\">Candida albicans<\/em> reacting favorably: serotonin and probably psilocin also inhibit the transition to the aggressive hyphae form, thus limiting the risk of overgrowth.<\/p><p data-start=\"1338\" data-end=\"1955\">On the other hand, psilocybin can also be a <strong data-start=\"1379\" data-end=\"1399\">negative effect<\/strong> have. Bacteria that use it <strong data-start=\"1443\" data-end=\"1459\">LasR system<\/strong>, as <em data-start=\"1467\" data-end=\"1491\">Pseudomonas aeruginosa<\/em>, They may actually respond with an increase in virulence. Under the influence of serotonin and psilocin, they form more biofilms and produce harmful enzymes. This makes them more difficult to combat and can lead to more inflammation and symptoms, especially in people with a weakened immune system or a disrupted microbiome. Other bacteria with LasR-like systems, such as <em data-start=\"1866\" data-end=\"1888\">Burkholderia cepacia<\/em> en <em data-start=\"1892\" data-end=\"1917\">Acinetobacter baumannii<\/em>, Let's see similar reactions.<\/p><p data-start=\"1957\" data-end=\"2340\">It is therefore clear that psilocybin is not unequivocally \u201cgood\u201d or \u201cbad\u201d for the gut flora. The effect depends on the <strong data-start=\"2078\" data-end=\"2108\">present microorganisms<\/strong> and the balance in the microbiome. In healthy people with a stable gut flora, the beneficial effects may predominate, whereas in people with a lot of opportunistic bacteria, the adverse effects may be more noticeable.<\/p><p data-start=\"2342\" data-end=\"2826\">However, this must also be put in perspective. A psilocybin experience lasts on average <strong data-start=\"2439\" data-end=\"2450\">six hours<\/strong>. This means that the exposure of microbes to psilocybin is relatively short. For most microorganisms, the impact will be temporary and not permanently change the composition of the gut flora. At most, there may be some changes during and shortly after the session. <strong data-start=\"2717\" data-end=\"2755\">enhanced or weakened activity<\/strong>, which then decreases again once the substance has disappeared from the body.<\/p><p data-start=\"2828\" data-end=\"3295\">In summary: Psilocybin can theoretically contribute to a <strong data-start=\"2895\" data-end=\"2923\">less harmful behavior<\/strong>, which is beneficial for health, whereas in other microbes it is actually harmful. <strong data-start=\"3003\" data-end=\"3025\">stimulating effect<\/strong> It may be that this is temporarily detrimental. Given the short duration of a session, the impact on the microbiome is likely limited. Further research must clarify what the exact effect of psilocybin is on the gut microbiome.<strong> LasR system<\/strong> en <strong data-start=\"718\" data-end=\"739\">CpxA\/CpxR system<\/strong>.<strong>\u00a0<\/strong>We hope and expect that the effect on the CpxA\/CpxR system is greater than on the LasR system, as this would better explain the positive effects of psilocybin on lasting mood improvements.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9117700 e-flex e-con-boxed e-con e-parent\" data-id=\"9117700\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ccdb592 elementor-widget elementor-widget-heading\" data-id=\"ccdb592\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"psilocybine-microbioom-ontsteking-veroudering-en-leefstijl-een-verbonden-geheel\">Psilocybin, the microbiome, inflammation, aging and lifestyle: one interconnected whole<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1feca98 elementor-widget elementor-widget-text-editor\" data-id=\"1feca98\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"390\" data-end=\"745\">When we compare the different effects of psilocybin, a clear pattern emerges: the microbiome is the hub that connects everything together. The effect of psilocybin on microbes in the gut actually works by affecting inflammatory processes, cell aging, and even the ability to make and maintain healthy lifestyle choices.<\/p><p data-start=\"747\" data-end=\"1459\">One of the most important effects in the gut is that psilocybin acts on many microorganisms via the <strong data-start=\"847\" data-end=\"868\">CpxA\/CpxR system<\/strong> the <strong data-start=\"872\" data-end=\"895\">virulence reduced<\/strong>.This literally gives the immune system rest and ensures a <strong data-start=\"1111\" data-end=\"1137\">lower inflammation pressure<\/strong>.<\/p><p data-start=\"1461\" data-end=\"2124\">Less inflammation in the intestines translates into <strong data-start=\"1513\" data-end=\"1545\">healthier microbiome environment<\/strong>. A calmer gut flora produces more protective substances such as short-chain fatty acids, which in turn strengthen the intestinal wall and further inhibit inflammation. This cascade works its way into the rest of the body: lower inflammation levels mean less damage to cells and DNA. Chronic inflammation is after all an important accelerator of aging, among other things by accelerating telomere shortening, the protective caps on our DNA. By inhibiting inflammation and reducing cellular stress, psilocybin can indirectly contribute to <strong data-start=\"2098\" data-end=\"2121\">Healthy aging<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-bc15899 elementor-widget elementor-widget-image\" data-id=\"bc15899\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"1667\" height=\"794\" src=\"https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome.avif\" class=\"attachment-full size-full wp-image-52998\" alt=\"Research on psilocybin in the gut\" srcset=\"https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome.avif 1667w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome-300x143.png 300w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome-1024x488.png 1024w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome-768x366.png 768w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome-1536x732.png 1536w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilobiome-18x9.png 18w\" sizes=\"auto, (max-width: 1667px) 100vw, 1667px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-84e4020 elementor-widget elementor-widget-text-editor\" data-id=\"84e4020\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"2126\" data-end=\"2713\">This creates a synergistic effect: the microbiome influences inflammation, inflammation influences aging, and psilocybin intervenes at all these levels simultaneously. The psychological effect of psilocybin also plays a role in this. During a session, people often gain new insights and more motivation to live healthier lives. This behavioral change has direct consequences on the microbiome: a fiber-rich diet, more exercise, better sleep, and less stress strengthen the gut flora, further supporting the anti-inflammatory and anti-aging effects of psilocybin.<\/p><p data-start=\"2715\" data-end=\"3227\">Thus psilocybin forms a <strong data-start=\"2740\" data-end=\"2772\">Bridge between mind and body<\/strong>. In the gut, it influences microbes and inflammation levels; in the brain, it opens up space for new patterns and behavioral choices. Both routes reinforce each other through the microbiota\u2013gut\u2013brain axis. Ultimately, a vicious cycle of positive change emerges: a calmer microbiome leads to less inflammation, which slows cell aging and clears the way for sustainable lifestyle improvements, which in turn further strengthen the microbiome.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7f70cf9 e-flex e-con-boxed e-con e-parent\" data-id=\"7f70cf9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8be2fbe elementor-widget elementor-widget-heading\" data-id=\"8be2fbe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"conclusie-en-bronnen\">Conclusion and sources<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b4eecc0 e-flex e-con-boxed e-con e-parent\" data-id=\"b4eecc0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-0e1ae24 e-con-full e-flex e-con e-child\" data-id=\"0e1ae24\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-da61d5f elementor-widget elementor-widget-text-editor\" data-id=\"da61d5f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"2715\" data-end=\"3227\">The potential positive effects of psilocybin on the microbiome are not in themselves. They form the starting point of a chain reaction that impacts inflammation, aging, and behavior. It is this holistic interconnectedness that explains why psilocybin can not only bring about spiritual enlightenment but could also have tangible physical health benefits.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f13ec2f elementor-widget elementor-widget-text-editor\" data-id=\"f13ec2f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"2715\" data-end=\"3227\">At the same time, it is important to emphasize that many of these findings have so far been based primarily on <strong data-start=\"602\" data-end=\"627\">Preclinical research<\/strong> (cells and mice) arrive. On a large scale and for a long time <strong data-start=\"680\" data-end=\"704\">Research in humans<\/strong> Further research is needed to confirm the extent to which psilocybin actually works as an anti-inflammatory, anti-aging, or microbiome-modulating agent.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4b9f87e e-con-full e-flex e-con e-child\" data-id=\"4b9f87e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c3f17cd elementor-widget elementor-widget-image\" data-id=\"c3f17cd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"300\" height=\"298\" src=\"https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilocybine-efffect-300x298.png\" class=\"attachment-medium size-medium wp-image-53003\" alt=\"Physical effects of psilocybin\" srcset=\"https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilocybine-efffect-300x298.png 300w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilocybine-efffect-150x150.png 150w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilocybine-efffect-768x764.png 768w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilocybine-efffect-12x12.png 12w, https:\/\/triptherapie.nl\/wp-content\/uploads\/2025\/08\/psilocybine-efffect.avif 901w\" sizes=\"auto, (max-width: 300px) 100vw, 300px\" title=\"\">\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-aac3fb8 e-flex e-con-boxed e-con e-parent\" data-id=\"aac3fb8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9ba9c0a elementor-widget elementor-widget-text-editor\" data-id=\"9ba9c0a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p data-start=\"848\" data-end=\"1200\">What is already clear is that psilocybin forms a powerful bridge between the mind and the body. It can provide insights and motivation to live healthier, and it is precisely these lifestyle changes that have a proven positive effect on the gut flora, inflammation, and aging. This creates a synergy between psychological, biological, and lifestyle processes.<\/p><p data-start=\"1202\" data-end=\"1499\">This blog is based on our own articles and insights, supplemented with scientific sources. Through the buttons below you can find more information about the physical effects of psilocybin, the research we refer to, and the possibility to sign up for psilocybin therapy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-40a478c e-flex e-con-boxed e-con e-parent\" data-id=\"40a478c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-568f96f elementor-widget elementor-widget-button\" data-id=\"568f96f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/pmc.ncbi.nlm.nih.gov\/articles\/PMC9791138\/\" target=\"_blank\" rel=\"nofollow noopener\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Source of research<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e50ff28 elementor-widget elementor-widget-button\" data-id=\"e50ff28\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/psilocybin-therapy-3\/#psilocybine-sessies-bij-triptherapie\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Psilocybin therapy<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Psilocybin not only gives you a trip, but can even affect the bacteria and fungi in your intestines! That way, you\u2019re also changing your microbiome.<\/p>","protected":false},"author":1,"featured_media":53022,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[],"class_list":["post-52956","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry"],"_links":{"self":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/posts\/52956","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/comments?post=52956"}],"version-history":[{"count":0,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/posts\/52956\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/media\/53022"}],"wp:attachment":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/media?parent=52956"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/categories?post=52956"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/tags?post=52956"}],"curies":[{"name":"Well played","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}