{"id":53072,"date":"2025-09-12T14:28:41","date_gmt":"2025-09-12T12:28:41","guid":{"rendered":"https:\/\/triptherapie.nl\/?p=53072"},"modified":"2025-09-12T14:28:46","modified_gmt":"2025-09-12T12:28:46","slug":"lsd-session-anxiety-best-dosage-science","status":"publish","type":"post","link":"https:\/\/triptherapie.nl\/en\/lsd-sessie-angst-beste-dosering-wetenschap\/","title":{"rendered":"LSD session for generalised anxiety disorder"},"content":{"rendered":"
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LSD and anxiety disorders<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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At Triptherapie, we are supporting more and more people who are struggling with generalised anxiety disorder (GAD). This condition is known for chronic worrying, tension and a feeling of insecurity that can severely impact daily life. Standard therapies and medication, such as SSRIs or benzodiazepines, do not always provide the desired relief and are often not sustainable.<\/p>

The revival of research into psychedelics is changing that. LSD (lysergide) in particular is back in the spotlight as a potential treatment for anxiety disorders. The intriguing thing is that a single session can provide months of reduction in anxiety symptoms. But what is the best dosage for anxiety reduction?<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Science and the correct LSD dosage?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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In September 2025, JAMA Psychiatry published the largest modern clinical study to date on LSD for generalised anxiety disorder. In this study, 198 adults with a moderate to severe anxiety disorder were randomly assigned to different groups. Each participant received a single dose of 25, 50, 100 or 200 micrograms of LSD (MM120, pharmaceutical tartrate) or a placebo, after which they were monitored for several months.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tLSD research<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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25 to 50 \u00b5g<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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At these lower doses, the researchers observed hardly any difference compared to the placebo group. This suggests that microdoses or very low doses for severe anxiety are often too subtle to achieve a clear therapeutic effect. Although some people experience a slight improvement in mood or focus with microdosing, in this study this proved insufficient to cause a significant reduction in generalised anxiety.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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100 \u00b5g<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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This dosage yielded the best results. Participants reported a clear and clinically relevant reduction in their anxiety symptoms, which moreover persisted for at least 12 weeks after the session. The effect was greater than in the placebo group and lasted much longer than what we typically see with traditional medication, where symptoms often return quickly after stopping.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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200 \u00b5g<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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At this higher dosage, a clear reduction in anxiety also occurred, comparable to the 100 \u00b5g group. However, the researchers noted that the experience was often more intense and sometimes accompanied by temporary discomforts, such as anxious moments or physical restlessness during the peak. Despite this intensity, many participants subsequently reported a sense of relief and greater acceptance.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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What makes this study extra special is that psychotherapy was not permitted during the sessions. The participants were merely guided and monitored in a safe, pleasant environment, but without therapeutic intervention or in-depth guidance. Nevertheless, the effects on anxiety reduction proved to be strong and long-lasting. Coincidentally, a week or so ago and before this research was published, we wrote that psychotherapy is often unnecessary for effectiveness. You can read how that comes about and the biological mechanism behind the positive effect of psychedelics here:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tPsychedelics without therapy<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Combining LSD with psilocybin or MDMA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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Alongside LSD sessions, we also sometimes use combinations of substances. We always do this carefully, with a focus on safety, personal circumstances, and therapeutic goals. Not every client has the same need or reacts the same way to a specific dose. Therefore, we determine the best approach on an individual basis, and other conditions alongside the anxiety may play a role in choosing a particular combination.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Wizard flip (LSD + psilocybin)<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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For clients struggling with both anxiety and depression, the so-called wizard flip (the combination of LSD and psilocybin) often proves particularly valuable.<\/p>