{"id":53072,"date":"2025-09-12T14:28:41","date_gmt":"2025-09-12T12:28:41","guid":{"rendered":"https:\/\/triptherapie.nl\/?p=53072"},"modified":"2025-09-12T14:28:46","modified_gmt":"2025-09-12T12:28:46","slug":"lsd-session-anxiety-best-dosage-science","status":"publish","type":"post","link":"https:\/\/triptherapie.nl\/en\/lsd-sessie-angst-beste-dosering-wetenschap\/","title":{"rendered":"LSD session for generalized anxiety disorder"},"content":{"rendered":"
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LSD and anxiety disorders<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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At Triptherapie, we support a growing number of people struggling with generalized anxiety disorder (GAD). This condition is known for its chronic worry, tension, and feelings of insecurity that can severely impact daily life. Conventional therapies and medications, such as SSRIs or benzodiazepines, don't always provide the desired relief and are often not sustainable.<\/p>

The resurgence of psychedelic research is changing that. LSD (lysergide), in particular, is attracting renewed interest as a potential treatment for anxiety disorders. Intriguingly, a single session can reduce anxiety symptoms for months. But what is the best dosage for anxiety reduction?<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Science and the correct LSD dosage?<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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In September 2025, the largest modern clinical trial of LSD in generalized anxiety disorder was published in JAMA Psychiatry. In this study, 198 adults with moderate to severe anxiety disorders were randomly assigned to different groups. Each participant received a single dose of 25, 50, 100, or 200 micrograms of LSD (MM120, pharmaceutical grade tartrate) or a placebo, after which they were monitored for several months.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tLSD research<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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25 and 50 \u00b5g<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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At these lower doses, the researchers saw little difference compared to the placebo group. This suggests that microdoses, or very low doses, for severe anxiety are often too subtle to achieve a clear therapeutic effect. While some people experience a slight improvement in mood or focus with microdosing, in this study, this was not enough to cause a significant reduction in generalized anxiety.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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100 \u00b5g<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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This dosage yielded the best results. Participants reported a clear and clinically relevant reduction in their anxiety symptoms, which lasted for at least 12 weeks after the session. The effect was greater than in the placebo group and lasted much longer than what we typically see with traditional medications, where symptoms often return quickly after discontinuation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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200 \u00b5g<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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This higher dose also showed a significant reduction in anxiety, comparable to the 100 mcg group. However, the researchers noted that the experience was often more intense and sometimes accompanied by temporary discomfort, such as moments of anxiety or physical restlessness during the peak. Despite this intensity, many participants reported a sense of relief and greater acceptance afterward.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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What makes this study particularly special is that psychotherapy was not permitted during the sessions. Participants were guided and monitored solely in a safe, comfortable space, but without any in-depth therapeutic intervention or guidance. Nevertheless, the effects on anxiety reduction proved to be strong and long-lasting. Coincidentally, we wrote about a week or so ago, before this study was published, that psychotherapy is often unnecessary for effectiveness. You can read more about this and the biological mechanism behind the positive effect of psychedelics here:<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t

\n\t\t\t\t\t\t\t\t\t\t\n\t\t\t\t\t\t\n\t\t\t\t\t\t\t\t\tPsychedelics without therapy<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t
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Combining LSD with psilocybin or MDMA<\/h2>\t\t\t\t<\/div>\n\t\t\t\t
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In addition to LSD sessions, we sometimes use combinations of substances. We always do this carefully, with an eye for safety, personal circumstances, and therapeutic goals. Not every client has the same needs or responds in the same way to a particular dose. Therefore, we consider the best approach for each individual, and other conditions besides anxiety may also influence the choice of a particular combination.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t

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Wizard flip (LSD + psilocybin)<\/h3>\t\t\t\t<\/div>\n\t\t\t\t
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For clients struggling with both anxiety and depression, the so-called wizard flip (the combination of LSD and psilocybin) often proves particularly valuable.<\/p>