{"id":53394,"date":"2025-09-29T15:13:20","date_gmt":"2025-09-29T13:13:20","guid":{"rendered":"https:\/\/triptherapie.nl\/?p=53394"},"modified":"2025-10-03T11:28:28","modified_gmt":"2025-10-03T09:28:28","slug":"the-effect-of-psilocybin-on-the-brain","status":"publish","type":"post","link":"https:\/\/triptherapie.nl\/en\/het-effect-van-psilocybine-op-de-hersenen\/","title":{"rendered":"The effect of psilocybin on the brain"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"53394\" class=\"elementor elementor-53394\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a6ce0a8 e-flex e-con-boxed e-con e-parent\" data-id=\"a6ce0a8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e4118c3 elementor-widget elementor-widget-heading\" data-id=\"e4118c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"psilocybine-en-het-brein\">Psilocybin and the brain<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b71c1e2 e-flex e-con-boxed e-con e-parent\" data-id=\"b71c1e2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-edc1c59 e-con-full e-flex e-con e-child\" data-id=\"edc1c59\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5517210 elementor-widget elementor-widget-text-editor\" data-id=\"5517210\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>When psilocybin from truffles or mushrooms is converted into psilocin in the body, a remarkable journey through the brain begins. This active molecule binds primarily to the 5-HT\u2082A receptors, which are present in high concentrations in various brain regions. The result is a chain of changes in perception, emotion, and consciousness, which together explain the intensity and depth of a psychedelic experience. To understand why a psilocybin session can have such a powerful effect, it&#039;s valuable to examine how psilocin exerts its influence on each brain region. In this blog post, we&#039;ll take you step by step through the brain&#039;s most important pathways. We&#039;ll go from the neocortex to the amygdala and from the hippocampus to the vagus nerve. Discover how their interaction makes the unique experience of a truffle journey possible.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3e72b6a e-con-full e-flex e-con e-child\" data-id=\"3e72b6a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-94e6058 elementor-widget elementor-widget-video\" data-id=\"94e6058\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=WiLhAOaBkSA&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-808ac84 e-flex e-con-boxed e-con e-parent\" data-id=\"808ac84\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4ecc994 elementor-widget elementor-widget-heading\" data-id=\"4ecc994\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"neocortex\">Neocortex<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-64d4093 e-grid e-con-boxed e-con e-parent\" data-id=\"64d4093\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f5e0209 e-con-full e-flex e-con e-child\" data-id=\"f5e0209\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63e3499 elementor-widget elementor-widget-heading\" data-id=\"63e3499\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Normal role<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5348616 elementor-widget elementor-widget-text-editor\" data-id=\"5348616\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The neocortex, especially the associative areas in the frontal and parietal cortex, is where abstract thought, self-awareness, planning, and meaning-making take place. Within the <strong data-start=\"586\" data-end=\"616\">default mode network (DMN)<\/strong> The medial prefrontal cortex and the posterior cingulate cortex form hubs that govern your self-image, reflection, and internal dialogue. This network dominates at rest, while it is suppressed during external tasks.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f7eef59 e-con-full e-flex e-con e-child\" data-id=\"f7eef59\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-23d814a elementor-widget elementor-widget-heading\" data-id=\"23d814a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dc998e8 elementor-widget elementor-widget-text-editor\" data-id=\"dc998e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The neocortex contains the highest concentration of <strong data-start=\"916\" data-end=\"937\">5-HT\u2082A receptors<\/strong>, particularly in layers III and V of the pyramidal cells. These cells are crucial for long-distance communication between brain regions. It is precisely this distribution that explains why psychedelics have such a powerful effect on perception and cognition.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7458cda e-con-full e-flex e-con e-child\" data-id=\"7458cda\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b9e17e1 elementor-widget elementor-widget-heading\" data-id=\"b9e17e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effect of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8178f8c elementor-widget elementor-widget-text-editor\" data-id=\"8178f8c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>When psilocin binds to the 5-HT\u2082A receptors, it increases the excitability of the pyramidal cells. The result is a <strong data-start=\"1340\" data-end=\"1377\">desynchronization of brain rhythms<\/strong>Alpha and beta waves (which normally bring stability and predictability to your cognition) decrease, creating a state in which networks function less rigidly. The DMN loses its dominant control, causing &quot;rigid priors&quot; (fixed assumptions and thought patterns) to loosen. Subjectively, this can feel like &quot;ego dissolution&quot;\u2014a sense of blurring the boundaries between yourself and the world.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a029417 e-con-full e-flex e-con e-child\" data-id=\"a029417\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-577930c elementor-widget elementor-widget-heading\" data-id=\"577930c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7ba0e09 elementor-widget elementor-widget-text-editor\" data-id=\"7ba0e09\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Because the neocortex loses its tight grip, other brain areas gain greater influence. Sensory input is perceived more strongly, emotions from the limbic system are felt more intensely, and old memories are more easily reintegrated. Post-acutely, this temporary flexibility is transformed into structural plasticity: studies show that dendritic spines in the frontal cortex remain larger and more numerous for weeks after psilocybin, suggesting lasting changes in connectivity and learning ability.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b230777 e-flex e-con-boxed e-con e-parent\" data-id=\"b230777\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d618749 elementor-widget elementor-widget-heading\" data-id=\"d618749\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"anterior-cingulate-gyrus\">Anterior Cingulate Gyrus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ffe755f e-grid e-con-boxed e-con e-parent\" data-id=\"ffe755f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f9e433b e-con-full e-flex e-con e-child\" data-id=\"f9e433b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-125ed7e elementor-widget elementor-widget-heading\" data-id=\"125ed7e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Normal role<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dc4ccaa elementor-widget elementor-widget-text-editor\" data-id=\"dc4ccaa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The anterior cingulate gyrus (ACC) is a crucial link between emotion and cognition. It monitors errors and conflicts, shifts attention to relevant stimuli, and regulates pain and emotional charge. The ACC is part of the <strong data-start=\"2671\" data-end=\"2691\">salience network<\/strong>, which decides which stimuli are important enough to focus your attention on.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-959b23a e-con-full e-flex e-con e-child\" data-id=\"959b23a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ecf1d7b elementor-widget elementor-widget-heading\" data-id=\"ecf1d7b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bdc212 elementor-widget elementor-widget-text-editor\" data-id=\"9bdc212\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The ACC is one of the cortex areas with a lot of <strong data-start=\"2845\" data-end=\"2866\">5-HT\u2082A receptors<\/strong>, which makes it susceptible to psychedelic influences.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8ac1008 e-con-full e-flex e-con e-child\" data-id=\"8ac1008\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3cc8be8 elementor-widget elementor-widget-heading\" data-id=\"3cc8be8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effect of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f0d38b8 elementor-widget elementor-widget-text-editor\" data-id=\"f0d38b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Under the influence of psilocin, the ACC becomes less strict in its transmission of salience information. This means that not only threats or important external tasks are prioritized, but also subtle, often ignored signals (interoceptive, emotional, or spiritual) can enter consciousness. This can lead to a feeling of experiencing emotions more &quot;honestly&quot; or intensely. Simultaneously, flexibility in cognitive control increases, which is why people often find themselves more open to new perspectives during a session.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8731af3 e-con-full e-flex e-con e-child\" data-id=\"8731af3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c139afb elementor-widget elementor-widget-heading\" data-id=\"c139afb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9f8da93 elementor-widget elementor-widget-text-editor\" data-id=\"9f8da93\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Because the ACC influences both the amygdala (fear\/emotion) and the prefrontal cortex (logical thinking), psilocin can integrate emotions and cognition in a new way. This explains why people often emerge from a session with greater self-compassion or empathy: the rational and emotional are no longer seen as opposing forces, but as complementary sources of wisdom.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-26c7370 e-flex e-con-boxed e-con e-parent\" data-id=\"26c7370\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-97eaa9f elementor-widget elementor-widget-heading\" data-id=\"97eaa9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"caudate-nucleus\">Caudate nucleus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4476169 e-grid e-con-boxed e-con e-parent\" data-id=\"4476169\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-de09624 e-con-full e-flex e-con e-child\" data-id=\"de09624\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-62c511f elementor-widget elementor-widget-heading\" data-id=\"62c511f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Normal role<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-23f6fab elementor-widget elementor-widget-text-editor\" data-id=\"23f6fab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0The caudate nucleus is part of the striatum and is strongly involved in <strong data-start=\"4075\" data-end=\"4147\">habitual behavior, decision-making, and loops of recurring thoughts<\/strong>. In collaboration with the thalamus and cortex, it forms cortico-striatal-thalamo-cortical (CSTC) loops that maintain both motor and cognitive habits.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bc7db73 e-con-full e-flex e-con e-child\" data-id=\"bc7db73\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c01f3a4 elementor-widget elementor-widget-heading\" data-id=\"c01f3a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65970d5 elementor-widget elementor-widget-text-editor\" data-id=\"65970d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>There are fewer 5-HT\u2082A receptors present here than in the cortex, but there are still relevant quantities <strong data-start=\"4434\" data-end=\"4444\">5-HT\u2082C<\/strong> and <strong data-start=\"4448\" data-end=\"4473\">dopaminergic modulation<\/strong> which are influenced indirectly via serotonergic systems.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b10f304 e-con-full e-flex e-con e-child\" data-id=\"b10f304\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b88deeb elementor-widget elementor-widget-heading\" data-id=\"b88deeb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effect of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e30e6fe elementor-widget elementor-widget-text-editor\" data-id=\"e30e6fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Psychedelics &quot;loosen&quot; the CSTC loops. This means that fixed patterns \u2013 such as worrying or obsessive thought patterns \u2013 are temporarily interrupted. Functional research with LSD (very similar to psilocin) shows that the <strong data-start=\"4798\" data-end=\"4854\">feedback dynamics between thalamus, striatum and cortex<\/strong> changes, which is subjectively experienced as space or flexibility in thinking and doing.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0763404 e-con-full e-flex e-con e-child\" data-id=\"0763404\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4d7ebc5 elementor-widget elementor-widget-heading\" data-id=\"4d7ebc5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f090f4 elementor-widget elementor-widget-text-editor\" data-id=\"1f090f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>This relaxation allows new behavioral strategies or insights to emerge. This explains why psychedelics have therapeutic potential for obsessive-compulsive disorders and addiction: the system that rigidly repeats normal behavior and thoughts temporarily becomes less dominant, allowing you to explore new paths.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6723e02 e-flex e-con-boxed e-con e-parent\" data-id=\"6723e02\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-616cecb elementor-widget elementor-widget-heading\" data-id=\"616cecb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"hypothalamus\">Hypothalamus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a2a2736 e-grid e-con-boxed e-con e-parent\" data-id=\"a2a2736\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7b5d7e1 e-con-full e-flex e-con e-child\" data-id=\"7b5d7e1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1f23e29 elementor-widget elementor-widget-heading\" data-id=\"1f23e29\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Normal role<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d2430cc elementor-widget elementor-widget-text-editor\" data-id=\"d2430cc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Through input from the cortex and limbic structures (particularly the amygdala and hippocampus), psilocin indirectly affects the hypothalamus. This can cause bodily sensations to change during a session: you might feel warmer or colder, less or more thirsty, or notice a shift in sexual energy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c06abea e-con-full e-flex e-con e-child\" data-id=\"c06abea\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0fd76dc elementor-widget elementor-widget-heading\" data-id=\"0fd76dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9e2516b elementor-widget elementor-widget-text-editor\" data-id=\"9e2516b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The hypothalamus has serotonergic innervation, including. <strong data-start=\"5604\" data-end=\"5614\">5-HT\u2081A<\/strong> and <strong data-start=\"5618\" data-end=\"5628\">5-HT\u2082A<\/strong>-receptors, although the density is lower than in the cortex.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-64b6a02 e-con-full e-flex e-con e-child\" data-id=\"64b6a02\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22ed61f elementor-widget elementor-widget-heading\" data-id=\"22ed61f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effect of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f1fc087 elementor-widget elementor-widget-text-editor\" data-id=\"f1fc087\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Through input from the cortex and limbic structures (particularly the amygdala and hippocampus), psilocin indirectly affects the hypothalamus. This can cause bodily sensations to change during a session: you might feel warmer or colder, less or more thirsty, or notice a shift in sexual energy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cae4f86 e-con-full e-flex e-con e-child\" data-id=\"cae4f86\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-178c656 elementor-widget elementor-widget-heading\" data-id=\"178c656\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17e3c51 elementor-widget elementor-widget-text-editor\" data-id=\"17e3c51\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Because the hypothalamus influences hormonal systems, psilocin can also <strong data-start=\"6118\" data-end=\"6140\">stress axis (HPA axis)<\/strong> Modulate. This can lead to feelings of relaxation and connection, as cortisol responses are dampened and oxytocin\/serotonin systems are more active. This explains the profound physical calm and security that many users experience.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8e966a1 e-flex e-con-boxed e-con e-parent\" data-id=\"8e966a1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4aa3692 elementor-widget elementor-widget-heading\" data-id=\"4aa3692\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"amygdala\">Amygdala<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b1841f3 e-grid e-con-boxed e-con e-parent\" data-id=\"b1841f3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-8730d75 e-con-full e-flex e-con e-child\" data-id=\"8730d75\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-353230a elementor-widget elementor-widget-heading\" data-id=\"353230a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Normal role<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-134d105 elementor-widget elementor-widget-text-editor\" data-id=\"134d105\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The amygdala is the emotional center of the brain and plays a crucial role in perceiving threats, regulating fear responses, and linking emotions to memories. Through this function, the amygdala largely determines how intensely we experience events and how emotional experiences are stored in our memory.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-36ecd76 e-con-full e-flex e-con e-child\" data-id=\"36ecd76\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4e26cf5 elementor-widget elementor-widget-heading\" data-id=\"4e26cf5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c799154 elementor-widget elementor-widget-text-editor\" data-id=\"c799154\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The amygdala has both <strong data-start=\"6629\" data-end=\"6639\">5-HT\u2081A<\/strong> as <strong data-start=\"6644\" data-end=\"6654\">5-HT\u2082A<\/strong>-receptors, which modulate its reactivity.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1d7c6ee e-con-full e-flex e-con e-child\" data-id=\"1d7c6ee\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f66f3d6 elementor-widget elementor-widget-heading\" data-id=\"f66f3d6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effect of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46b5a67 elementor-widget elementor-widget-text-editor\" data-id=\"46b5a67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>During the acute trip, amygdala activity often decreases, especially in response to emotionally negative stimuli. In healthy participants, this leads to a more positive mood. In patients with depression, it has been observed that the amygdala activity decreases in the days following the session. <strong data-start=\"6991\" data-end=\"7021\">more emotionally responsive<\/strong> becomes. This is not in the sense of fear, but in the sense of openness to allow emotions.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-18a67ba e-con-full e-flex e-con e-child\" data-id=\"18a67ba\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1f8e07f elementor-widget elementor-widget-heading\" data-id=\"1f8e07f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b374e05 elementor-widget elementor-widget-text-editor\" data-id=\"b374e05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>This two-phase effect makes therapy more powerful: during the session, anxiety is reduced, allowing you to explore difficult topics. After the session, emotional responsiveness is restored, so that new insights are not suppressed but rather experienced.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8dee86e e-flex e-con-boxed e-con e-parent\" data-id=\"8dee86e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6943f5a elementor-widget elementor-widget-heading\" data-id=\"6943f5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"hippocampus\">Hippocampus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-353d218 e-grid e-con-boxed e-con e-parent\" data-id=\"353d218\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7632d48 e-con-full e-flex e-con e-child\" data-id=\"7632d48\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8b77188 elementor-widget elementor-widget-heading\" data-id=\"8b77188\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Normal role<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54e60bc elementor-widget elementor-widget-text-editor\" data-id=\"54e60bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The hippocampus is the brain&#039;s memory center, responsible for recording new memories and placing them in context. It also gives meaning to events by linking them to emotions, working closely with the amygdala. At the same time, the hippocampus maintains close contact with the cortex, where memories are ultimately stored long-term. In this way, the hippocampus forms a link between present-day experience and the enduring narratives that shape our self-image and life history.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a63a42 e-con-full e-flex e-con e-child\" data-id=\"0a63a42\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-98b8fc8 elementor-widget elementor-widget-heading\" data-id=\"98b8fc8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a6e453 elementor-widget elementor-widget-text-editor\" data-id=\"7a6e453\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The hippocampus is rich in <strong data-start=\"7692\" data-end=\"7713\">5-HT\u2081A receptors<\/strong> and also contains 5-HT\u2082A, albeit in lower concentrations than the cortex.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9e5ede9 e-con-full e-flex e-con e-child\" data-id=\"9e5ede9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4f650c3 elementor-widget elementor-widget-heading\" data-id=\"4f650c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effect of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3fa6c47 elementor-widget elementor-widget-text-editor\" data-id=\"3fa6c47\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Under the influence of psilocin, memories can be recalled and placed in a new emotional framework. This is associated with <strong data-start=\"7956\" data-end=\"7996\">rapid neuroplastic changes<\/strong>: dendritic spine growth, increased BDNF expression and activation of the <strong data-start=\"8070\" data-end=\"8087\">mTOR\/TrkB pathway<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-51bf669 e-con-full e-flex e-con e-child\" data-id=\"51bf669\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-378c5d8 elementor-widget elementor-widget-heading\" data-id=\"378c5d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3162332 elementor-widget elementor-widget-text-editor\" data-id=\"3162332\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The result is that old memories don&#039;t disappear, but their meaning can change. Traumas can be relived with more gentleness, allowing the brain to create a new narrative around the same events\u2014a crucial step in psychotherapeutic recovery.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6c7c1c9 e-flex e-con-boxed e-con e-parent\" data-id=\"6c7c1c9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-31bf64c elementor-widget elementor-widget-heading\" data-id=\"31bf64c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"thalamus\">Thalamus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3107cf7 e-grid e-con-boxed e-con e-parent\" data-id=\"3107cf7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7060651 e-con-full e-flex e-con e-child\" data-id=\"7060651\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8241d49 elementor-widget elementor-widget-heading\" data-id=\"8241d49\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Normal role<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-804b856 elementor-widget elementor-widget-text-editor\" data-id=\"804b856\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The thalamus functions as a central relay station in the brain, determining which stimuli from the senses are passed on to the cortex. It filters sound, images, touch, and internal signals, ensuring that only the most relevant information reaches our consciousness. In this way, the thalamus plays a key role in attention and perception: it regulates whether we ignore a faint background noise or suddenly look up at an unexpected sound. As a gatekeeper between the external world and conscious thought, the thalamus largely determines how we experience reality.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b0b349d e-con-full e-flex e-con e-child\" data-id=\"b0b349d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fb2c413 elementor-widget elementor-widget-heading\" data-id=\"fb2c413\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3734ac8 elementor-widget elementor-widget-text-editor\" data-id=\"3734ac8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The thalamus has serotonergic receptors, but fewer than the cortex. Nevertheless, its central position means it plays a significant role in psilocin&#039;s effects.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-20a95e8 e-con-full e-flex e-con e-child\" data-id=\"20a95e8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a460df7 elementor-widget elementor-widget-heading\" data-id=\"a460df7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effect of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3dde795 elementor-widget elementor-widget-text-editor\" data-id=\"3dde795\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Psilocin disrupts thalamic filtering, allowing more and more intense stimuli to reach the cortex. This explains why sound, color, and touch are experienced more intensely. It can also cause hallucinations, as irrelevant or internal signals become conscious unfiltered.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-55ed1b6 e-con-full e-flex e-con e-child\" data-id=\"55ed1b6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4807c79 elementor-widget elementor-widget-heading\" data-id=\"4807c79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c16922 elementor-widget elementor-widget-text-editor\" data-id=\"2c16922\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The thalamus&#039;s increased permeability amplifies the sensory richness of a trip and contributes to synesthesia (when the senses blend). This abundance of input feeds the neocortex, which attempts to integrate it meaningfully.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4c95d7a e-flex e-con-boxed e-con e-parent\" data-id=\"4c95d7a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-10d3995 elementor-widget elementor-widget-heading\" data-id=\"10d3995\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"corpus-callosum\">Corpus callosum<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5ca3eab e-grid e-con-boxed e-con e-parent\" data-id=\"5ca3eab\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-38e1103 e-con-full e-flex e-con e-child\" data-id=\"38e1103\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f819ef elementor-widget elementor-widget-heading\" data-id=\"7f819ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Normal role<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-29a03b3 elementor-widget elementor-widget-text-editor\" data-id=\"29a03b3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The corpus callosum is a thick bundle of nerve fibers that connects the left and right hemispheres of the brain. This structure allows the two hemispheres to continuously exchange information and complement each other&#039;s functions. The left hemisphere, often more involved in language and analytical thinking, is thus coordinated with the right hemisphere, which specializes more in creativity, intuition, and holistic perception. The corpus callosum thus ensures that reason and emotion, logic and imagination, do not function separately but are interwoven into a seamless whole.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2618fbe e-con-full e-flex e-con e-child\" data-id=\"2618fbe\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9fb0234 elementor-widget elementor-widget-heading\" data-id=\"9fb0234\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-87bf953 elementor-widget elementor-widget-text-editor\" data-id=\"87bf953\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Although the fibers themselves do not contain receptors, the connected cortex areas are rich in 5-HT\u2082A.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-418e462 e-con-full e-flex e-con e-child\" data-id=\"418e462\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-981d404 elementor-widget elementor-widget-heading\" data-id=\"981d404\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effect of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-02c7ce1 elementor-widget elementor-widget-text-editor\" data-id=\"02c7ce1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Under psilocin, interhemispheric communication increases. People experience this as a merging of reason and emotion, or as images directly connected to language and meaning.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-416e513 e-con-full e-flex e-con e-child\" data-id=\"416e513\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-384ecac elementor-widget elementor-widget-heading\" data-id=\"384ecac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6dd01c3 elementor-widget elementor-widget-text-editor\" data-id=\"6dd01c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>This increased integration creates creative insights that make both logical and emotional sense \u2013 a rare synergy often experienced as a \u201crevelation.\u201d.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d8998ec e-flex e-con-boxed e-con e-parent\" data-id=\"d8998ec\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-61f2e16 elementor-widget elementor-widget-heading\" data-id=\"61f2e16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"cerebellum\">Cerebellum<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f5315d3 e-grid e-con-boxed e-con e-parent\" data-id=\"f5315d3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-fde10ea e-con-full e-flex e-con e-child\" data-id=\"fde10ea\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9fbc45d elementor-widget elementor-widget-heading\" data-id=\"9fbc45d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Normal role<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-93a6135 elementor-widget elementor-widget-text-editor\" data-id=\"93a6135\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The cerebellum, also known as the little brain, is traditionally known as the center that precisely coordinates movement and timing. It ensures the fluidity and precision of our actions, from walking and writing to playing music. Besides this motor role, the cerebellum also appears to be involved in emotional regulation and cognitive prediction: it helps predict what will happen next and thus contributes to smooth responses to the environment. This makes the cerebellum not just a motor organ but a sophisticated regulator that balances body, emotion, and thought.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-619a020 e-con-full e-flex e-con e-child\" data-id=\"619a020\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5f6f868 elementor-widget elementor-widget-heading\" data-id=\"5f6f868\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fd1fe83 elementor-widget elementor-widget-text-editor\" data-id=\"fd1fe83\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Serotonergic receptors are present, but the density is lower than in the associative cortex.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5c07751 e-con-full e-flex e-con e-child\" data-id=\"5c07751\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7865a18 elementor-widget elementor-widget-heading\" data-id=\"7865a18\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effect of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-70e17d4 elementor-widget elementor-widget-text-editor\" data-id=\"70e17d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The cerebellum shows that movements can be experienced more fluidly and breathing more consciously. The subjective experience of time also changes because the internal clock is influenced.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1649b0f e-con-full e-flex e-con e-child\" data-id=\"1649b0f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5e38739 elementor-widget elementor-widget-heading\" data-id=\"5e38739\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4097de elementor-widget elementor-widget-text-editor\" data-id=\"c4097de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>By connecting with sensory and frontal networks, the cerebellum enhances bodily harmony during a trip. This makes dance, breathing, or meditation feel extra connected and meaningful.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9e7b015 e-flex e-con-boxed e-con e-parent\" data-id=\"9e7b015\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef0f713 elementor-widget elementor-widget-heading\" data-id=\"ef0f713\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"brainstem-en-raphe\">Brainstem and raphe<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f493c01 e-grid e-con-boxed e-con e-parent\" data-id=\"f493c01\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-487c04a e-con-full e-flex e-con e-child\" data-id=\"487c04a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-68ddc72 elementor-widget elementor-widget-heading\" data-id=\"68ddc72\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Normal role<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-af5981a elementor-widget elementor-widget-text-editor\" data-id=\"af5981a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The raphe nuclei in the brainstem are the brain&#039;s primary source of serotonin. From these nuclei, widespread serotonergic projections are sent to virtually all brain areas, playing a central role in mood, sleep, pain perception, and emotional regulation. The brainstem itself also regulates fundamental bodily functions such as breathing, heart rate, and alertness or arousal. Together, the raphe nuclei and surrounding structures ensure that our brain can function in a stable physiological and emotional state, serving as a foundation upon which higher cognitive and emotional processes build.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-96afee1 e-con-full e-flex e-con e-child\" data-id=\"96afee1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c47964e elementor-widget elementor-widget-heading\" data-id=\"c47964e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a7703a elementor-widget elementor-widget-text-editor\" data-id=\"1a7703a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The raphe contains <strong data-start=\"11088\" data-end=\"11113\">5-HT\u2081A autoreceptors<\/strong>, which regulate their own rate of fire.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b2bba3a e-con-full e-flex e-con e-child\" data-id=\"b2bba3a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63a9613 elementor-widget elementor-widget-heading\" data-id=\"63a9613\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effect of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e37c7b4 elementor-widget elementor-widget-text-editor\" data-id=\"e37c7b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Psilocin activates these autoreceptors, temporarily reducing natural serotonin release. Simultaneously, it activates 5-HT\u2082A receptors elsewhere, leading to a brain-wide change in signal transmission.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a8a2da9 e-con-full e-flex e-con e-child\" data-id=\"a8a2da9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8aba054 elementor-widget elementor-widget-heading\" data-id=\"8aba054\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7313931 elementor-widget elementor-widget-text-editor\" data-id=\"7313931\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>This explains why psilocin isn&#039;t simply a &quot;serotonin boost,&quot; but a complete reconfiguration of serotonergic balance. Through connections with the nucleus tractus solitarius, it also affects the autonomic nervous system, resulting in altered heart rate, breathing, and feelings of relaxation or surrender.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d2f9128 e-flex e-con-boxed e-con e-parent\" data-id=\"d2f9128\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fa34ae2 elementor-widget elementor-widget-heading\" data-id=\"fa34ae2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"vagus-nerve\">Vagus nerve<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-362fac0 e-grid e-con-boxed e-con e-parent\" data-id=\"362fac0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-92f11f6 e-con-full e-flex e-con e-child\" data-id=\"92f11f6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5dc31ff elementor-widget elementor-widget-heading\" data-id=\"5dc31ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Normal role<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1125212 elementor-widget elementor-widget-text-editor\" data-id=\"1125212\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The vagus nerve is the tenth cranial nerve and forms a vital connection between the brain and the body. It sends signals from organs such as the heart, lungs, and intestines to the brain and vice versa. The ventral branch normally promotes social connection, calm, and safety. The dorsal branch, on the other hand, plays a role in immobilization and energy conservation, for example, during extreme stress or deep relaxation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b5ff135 e-con-full e-flex e-con e-child\" data-id=\"b5ff135\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f1deecb elementor-widget elementor-widget-heading\" data-id=\"f1deecb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a568efd elementor-widget elementor-widget-text-editor\" data-id=\"a568efd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The vagus nerve itself contains few serotonergic receptors. However, this nerve has strong connections to brain areas rich in 5-HT\u2082A receptors, such as the insula, the anterior cingulate cortex, and the prefrontal cortex. These brain areas can indirectly influence vagal activity. This explains why serotonergic substances like psilocin have a noticeable effect on the autonomic functions controlled by the vagus nerve.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1421ffb e-con-full e-flex e-con e-child\" data-id=\"1421ffb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5b02f54 elementor-widget elementor-widget-heading\" data-id=\"5b02f54\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effect of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-295a2ae elementor-widget elementor-widget-text-editor\" data-id=\"295a2ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Psilocin primarily activates 5-HT\u2082A receptors, altering communication patterns in brain areas related to the vagus nerve. This increases the ventral vagus nerve&#039;s activity, leading to feelings of warmth, love, connection, and safety. At higher doses, the balance can shift, and the dorsal vagus nerve becomes more involved, potentially leading to a state of surrender and immobility. Many people experience this as a form of &quot;ego death,&quot; in which the boundaries of the self temporarily collapse.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b1328cd e-con-full e-flex e-con e-child\" data-id=\"b1328cd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f762d75 elementor-widget elementor-widget-heading\" data-id=\"f762d75\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b7b25c1 elementor-widget elementor-widget-text-editor\" data-id=\"b7b25c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The first step is increased serotonergic activity in brain areas that regulate the vagus nerve. This translates into increased ventral vagal activity and a physiological state of safety. From there, a cascade of effects follows: relaxation of heart rate and breathing, a greater sense of connection with others, and a deep physical sense of calm. At higher doses, a shift toward dorsal vagal dominance occurs, which can manifest as a physical surrender or trance-like state. This combination of phases explains why psilocin can evoke both loving connection and transcendent letting go.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ffe6e12 e-flex e-con-boxed e-con e-parent\" data-id=\"ffe6e12\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef087ab elementor-widget elementor-widget-heading\" data-id=\"ef087ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"conclusie\">Conclusion<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f2d883 elementor-widget elementor-widget-text-editor\" data-id=\"7f2d883\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The journey psilocin triggers in the brain isn&#039;t limited to a single region but rather arises from the collaboration of many areas. By loosening the neocortex&#039;s fixed patterns, reducing the amygdala&#039;s fearful responses, allowing the hippocampus to reframe old memories, and strengthening the vagus nerve&#039;s sense of connection, a unique state of consciousness emerges. This temporary reconfiguration of the brain opens the door to greater flexibility in thinking and feeling, and can lead to profound insights, emotional processing, and lasting neuroplastic changes. This explains why psilocybin not only evokes a remarkable experience but also holds such great therapeutic potential for personal growth and recovery.<\/p><p>Those interested in learning more about how these changes are subjectively experienced can read more in our article about the truffle journey. For a more in-depth look at the effects of psilocybin and psilocin at the cellular level, we refer you to the article &quot;Psychotherapy with psychedelic therapy is often not necessary.&quot; This will provide insight into both the inner experience and the biological basis of these unique substances.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-65e3527 e-flex e-con-boxed e-con e-parent\" data-id=\"65e3527\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ff58255 elementor-widget elementor-widget-button\" data-id=\"ff58255\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/the-truffle-journey\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Subjective experience<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57f9fd9 elementor-widget elementor-widget-button\" data-id=\"57f9fd9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"#\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Psychedelics without therapy<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cee161c e-flex e-con-boxed e-con e-parent\" data-id=\"cee161c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4175793 elementor-widget elementor-widget-heading\" data-id=\"4175793\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"zelf-ervaren-onder-begeleiding\">Experience it yourself under supervision<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b553b0 elementor-widget elementor-widget-text-editor\" data-id=\"2b553b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>At Triptherapie, you can experience the effects of psilocybin and psilocin in a safe and meaningful way under the guidance of an experienced therapist or trip sitter. There are two steps to make an appointment. The first is completing the intake form, so we can thoroughly assess your health, intentions, and wishes. The second step is choosing and booking the session that best suits you, after which we will further develop the process together.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-456e6ba e-con-full e-flex e-con e-child\" data-id=\"456e6ba\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-40f425e elementor-align-center elementor-widget elementor-widget-button\" data-id=\"40f425e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/intake-trip-therapy\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-user-plus\" viewbox=\"0 0 640 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M624 208h-64v-64c0-8.8-7.2-16-16-16h-32c-8.8 0-16 7.2-16 16v64h-64c-8.8 0-16 7.2-16 16v32c0 8.8 7.2 16 16 16h64v64c0 8.8 7.2 16 16 16h32c8.8 0 16-7.2 16-16v-64h64c8.8 0 16-7.2 16-16v-32c0-8.8-7.2-16-16-16zm-400 48c70.7 0 128-57.3 128-128S294.7 0 224 0 96 57.3 96 128s57.3 128 128 128zm89.6 32h-16.7c-22.2 10.2-46.9 16-72.9 16s-50.6-5.8-72.9-16h-16.7C60.2 288 0 348.2 0 422.4V464c0 26.5 21.5 48 48 48h352c26.5 0 48-21.5 48-48v-41.6c0-74.2-60.2-134.4-134.4-134.4z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Online intake<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2545042 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"2545042\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/reservations\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-calendar-alt\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M148 288h-40c-6.6 0-12-5.4-12-12v-40c0-6.6 5.4-12 12-12h40c6.6 0 12 5.4 12 12v40c0 6.6-5.4 12-12 12zm108-12v-40c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v40c0 6.6 5.4 12 12 12h40c6.6 0 12-5.4 12-12zm96 0v-40c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v40c0 6.6 5.4 12 12 12h40c6.6 0 12-5.4 12-12zm-96 96v-40c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v40c0 6.6 5.4 12 12 12h40c6.6 0 12-5.4 12-12zm-96 0v-40c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v40c0 6.6 5.4 12 12 12h40c6.6 0 12-5.4 12-12zm192 0v-40c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v40c0 6.6 5.4 12 12 12h40c6.6 0 12-5.4 12-12zm96-260v352c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V112c0-26.5 21.5-48 48-48h48V12c0-6.6 5.4-12 12-12h40c6.6 0 12 5.4 12 12v52h128V12c0-6.6 5.4-12 12-12h40c6.6 0 12 5.4 12 12v52h48c26.5 0 48 21.5 48 48zm-48 346V160H48v298c0 3.3 2.7 6 6 6h340c3.3 0 6-2.7 6-6z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">To book<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Discover how psilocybin affects the brain and why this leads to profound changes in emotion, memory, and consciousness. Psilocybin activates the neocortex, causing patterns and perceptions to be experienced differently. In the anterior cingulate gyrus, it enhances emotional processing and self-reflection, while in the caudate nucleus, flexibility and new behaviors are promoted. The hypothalamus responds with changes in hormonal balance and body regulation. In the amygdala, psilocybin reduces the fear response and increases emotional openness. The hippocampus receives a boost in memory processing and the making of new connections. Through the thalamus, the filter of sensory information changes, making experiences more intense. The corpus callosum promotes increased communication between the cerebral hemispheres. The cerebellum supports altered body awareness and coordination. The brainstem and raphe nuclei, which produce serotonin, play a key role in mood and consciousness. Finally, psilocybin amplifies signals from the vagus nerve, which increases feelings of connection, safety, and relaxation.<\/p>","protected":false},"author":1,"featured_media":53561,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[],"tags":[1305,1302,1310,1303,1309,1308,1300,1306,1304,1301,11,1307,1311],"class_list":["post-53394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","tag-amygdala","tag-anterior-cingulate-gyrus","tag-brainstem","tag-caudate-nucleus","tag-cerebellum","tag-corpus-callosum","tag-hersenen","tag-hippocampus","tag-hypothalamus","tag-neocortex","tag-psilocybine","tag-thalamus","tag-vagus-nerve"],"_links":{"self":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/posts\/53394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/comments?post=53394"}],"version-history":[{"count":0,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/posts\/53394\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/media\/53561"}],"wp:attachment":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/media?parent=53394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/categories?post=53394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/tags?post=53394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}