{"id":53394,"date":"2025-09-29T15:13:20","date_gmt":"2025-09-29T13:13:20","guid":{"rendered":"https:\/\/triptherapie.nl\/?p=53394"},"modified":"2025-10-03T11:28:28","modified_gmt":"2025-10-03T09:28:28","slug":"the-effect-of-psilocybin-on-the-brain","status":"publish","type":"post","link":"https:\/\/triptherapie.nl\/en\/het-effect-van-psilocybine-op-de-hersenen\/","title":{"rendered":"The effect of psilocybin on the brain"},"content":{"rendered":"<div data-elementor-type=\"wp-post\" data-elementor-id=\"53394\" class=\"elementor elementor-53394\" data-elementor-post-type=\"post\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a6ce0a8 e-flex e-con-boxed e-con e-parent\" data-id=\"a6ce0a8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-e4118c3 elementor-widget elementor-widget-heading\" data-id=\"e4118c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"psilocybine-en-het-brein\">Psilocybin and the brain<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b71c1e2 e-flex e-con-boxed e-con e-parent\" data-id=\"b71c1e2\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-edc1c59 e-con-full e-flex e-con e-child\" data-id=\"edc1c59\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5517210 elementor-widget elementor-widget-text-editor\" data-id=\"5517210\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>When psilocybin from truffles or mushrooms is converted into psilocin in the body, a remarkable journey through the brain begins. This active molecule binds primarily to the 5-HT\u2082A receptors, which are present in high concentrations in various brain regions. The result is a chain of changes in perception, emotion and consciousness, which together explain the intensity and depth of a psychedelic experience. To understand why a psilocybin session can have such a powerful effect, it is valuable to look at how psilocin exerts its influence per brain region. In this blog, we take you step by step through the most important links in the brain. We go from the neocortex to the amygdala and from the hippocampus to the vagus nerve. Discover how their collaboration makes the unique experience of a truffle journey possible.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3e72b6a e-con-full e-flex e-con e-child\" data-id=\"3e72b6a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-94e6058 elementor-widget elementor-widget-video\" data-id=\"94e6058\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;youtube_url&quot;:&quot;https:\\\/\\\/www.youtube.com\\\/watch?v=WiLhAOaBkSA&quot;,&quot;video_type&quot;:&quot;youtube&quot;,&quot;controls&quot;:&quot;yes&quot;}\" data-widget_type=\"video.default\">\n\t\t\t\t\t\t\t<div class=\"elementor-wrapper elementor-open-inline\">\n\t\t\t<div class=\"elementor-video\"><\/div>\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-808ac84 e-flex e-con-boxed e-con e-parent\" data-id=\"808ac84\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4ecc994 elementor-widget elementor-widget-heading\" data-id=\"4ecc994\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"neocortex\">neocortex<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-64d4093 e-grid e-con-boxed e-con e-parent\" data-id=\"64d4093\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f5e0209 e-con-full e-flex e-con e-child\" data-id=\"f5e0209\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63e3499 elementor-widget elementor-widget-heading\" data-id=\"63e3499\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Standard roll<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-5348616 elementor-widget elementor-widget-text-editor\" data-id=\"5348616\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The neocortex, especially the associative areas in the frontal and parietal cortex, is where abstract thinking, self-awareness, planning and meaning-making take place. Within the <strong data-start=\"586\" data-end=\"616\">default mode network (DMN)<\/strong> form the medial prefrontal cortex and the posterior cingulate cortex nodes that direct your self-image, reflection and inner dialogue. At rest, this network predominates, whereas it is suppressed during external tasks.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f7eef59 e-con-full e-flex e-con e-child\" data-id=\"f7eef59\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-23d814a elementor-widget elementor-widget-heading\" data-id=\"23d814a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dc998e8 elementor-widget elementor-widget-text-editor\" data-id=\"dc998e8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The neocortex contains the highest concentration of <strong data-start=\"916\" data-end=\"937\">5-HT\u2082A receptors<\/strong>, especially in layers III and V of the pyramidal cells. These cells are crucial for long-distance communication between brain regions. It is precisely this distribution that explains why psychedelics have such a powerful effect on perception and cognition.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-7458cda e-con-full e-flex e-con e-child\" data-id=\"7458cda\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b9e17e1 elementor-widget elementor-widget-heading\" data-id=\"b9e17e1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-8178f8c elementor-widget elementor-widget-text-editor\" data-id=\"8178f8c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>When psilocin binds to the 5-HT\u2082A receptors, it increases the excitability of the pyramidal cells. The result is a <strong data-start=\"1340\" data-end=\"1377\">desynchronisation of brain rhythms<\/strong>alpha and beta waves (which normally bring stability and predictability to your cognition) decrease, and a state emerges in which networks function less strictly defined. The DMN loses its dominant control, allowing \u201crigid priors\u201d (fixed assumptions and thought patterns) to become looser. Subjectively, this can feel like \u201cego dissolution\u201d, a feeling that boundaries between yourself and the world are blurring.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a029417 e-con-full e-flex e-con e-child\" data-id=\"a029417\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-577930c elementor-widget elementor-widget-heading\" data-id=\"577930c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7ba0e09 elementor-widget elementor-widget-text-editor\" data-id=\"7ba0e09\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Because the neocortex loses its tight grip, other brain regions gain more influence. Sensory input comes through more strongly, emotions from the limbic system feel more intense, and old memories are more easily re-integrated. Post-acutely, you see that this temporary flexibility is converted into structural plasticity: studies show that dendritic spines in the frontal cortex are larger and more numerous up to weeks after psilocybin, indicating lasting changes in connectivity and learnability.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b230777 e-flex e-con-boxed e-con e-parent\" data-id=\"b230777\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-d618749 elementor-widget elementor-widget-heading\" data-id=\"d618749\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"anterior-cingulate-gyrus\">Anterior Cingulate Gyrus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ffe755f e-grid e-con-boxed e-con e-parent\" data-id=\"ffe755f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-f9e433b e-con-full e-flex e-con e-child\" data-id=\"f9e433b\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-125ed7e elementor-widget elementor-widget-heading\" data-id=\"125ed7e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Standard roll<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-dc4ccaa elementor-widget elementor-widget-text-editor\" data-id=\"dc4ccaa\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The anterior cingulate gyrus (ACC) is a crucial link between emotion and cognition. It monitors errors and conflicts, shifts attention to relevant stimuli, and regulates pain and emotional load. The ACC is part of the <strong data-start=\"2671\" data-end=\"2691\">salience network<\/strong>, which decides which stimuli are important enough to focus your attention on.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-959b23a e-con-full e-flex e-con e-child\" data-id=\"959b23a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ecf1d7b elementor-widget elementor-widget-heading\" data-id=\"ecf1d7b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9bdc212 elementor-widget elementor-widget-text-editor\" data-id=\"9bdc212\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The ACC is one of the cortical areas with many <strong data-start=\"2845\" data-end=\"2866\">5-HT\u2082A receptors<\/strong>, which makes it susceptible to psychedelic influence.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8ac1008 e-con-full e-flex e-con e-child\" data-id=\"8ac1008\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-3cc8be8 elementor-widget elementor-widget-heading\" data-id=\"3cc8be8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f0d38b8 elementor-widget elementor-widget-text-editor\" data-id=\"f0d38b8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Under the influence of psilocin, the ACC becomes less strict in passing on salience information. This means that not only threats or important external tasks are given priority, but subtle, often ignored signals (interoceptive, emotional or spiritual) can also break through into consciousness. This can lead to a feeling that you are experiencing your emotions more \u201chonestly\u201d or more intensely. At the same time, the flexibility in cognitive control increases, which means people often experience during a session that they are more open to new perspectives.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8731af3 e-con-full e-flex e-con e-child\" data-id=\"8731af3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c139afb elementor-widget elementor-widget-heading\" data-id=\"c139afb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9f8da93 elementor-widget elementor-widget-text-editor\" data-id=\"9f8da93\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Because the ACC exerts its influence on both the amygdala (fear\/emotion) and the prefrontal cortex (logical thinking), psilocin can integrate emotions and cognition in a novel way. This explains why people often emerge from a session with greater self-compassion or empathy: the rational and the emotional are no longer seen as opposing forces, but as complementary sources of wisdom.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-26c7370 e-flex e-con-boxed e-con e-parent\" data-id=\"26c7370\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-97eaa9f elementor-widget elementor-widget-heading\" data-id=\"97eaa9f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"caudate-nucleus\">caudate nucleus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4476169 e-grid e-con-boxed e-con e-parent\" data-id=\"4476169\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-de09624 e-con-full e-flex e-con e-child\" data-id=\"de09624\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-62c511f elementor-widget elementor-widget-heading\" data-id=\"62c511f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Standard roll<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-23f6fab elementor-widget elementor-widget-text-editor\" data-id=\"23f6fab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>\u00a0The caudate nucleus is part of the striatum and is heavily involved in <strong data-start=\"4075\" data-end=\"4147\">habitual behaviour, decision-making and loops of recurring thoughts<\/strong>. In collaboration with the thalamus and cortex, it forms cortico-striatal-thalamo-cortical (CSTC) loops that maintain both motor and cognitive habits.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-bc7db73 e-con-full e-flex e-con e-child\" data-id=\"bc7db73\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c01f3a4 elementor-widget elementor-widget-heading\" data-id=\"c01f3a4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-65970d5 elementor-widget elementor-widget-text-editor\" data-id=\"65970d5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Fewer 5-HT\u2082A receptors are present here than in the cortex, though still in relevant amounts <strong data-start=\"4434\" data-end=\"4444\">5-HT\u2082C<\/strong> en <strong data-start=\"4448\" data-end=\"4473\">dopaminergic modulation<\/strong> which are indirectly influenced via serotonergic systems.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b10f304 e-con-full e-flex e-con e-child\" data-id=\"b10f304\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-b88deeb elementor-widget elementor-widget-heading\" data-id=\"b88deeb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e30e6fe elementor-widget elementor-widget-text-editor\" data-id=\"e30e6fe\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Psychedelics loosen the CSTC loops. This means that fixed patterns \u2013 for example, rumination or obsessive thought loops \u2013 are temporarily interrupted. Functional research with LSD (which is very similar to psilocin) shows that the <strong data-start=\"4798\" data-end=\"4854\">feedback dynamics between thalamus, striatum and cortex<\/strong> changes, which is subjectively experienced as space or flexibility in thought and action.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0763404 e-con-full e-flex e-con e-child\" data-id=\"0763404\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4d7ebc5 elementor-widget elementor-widget-heading\" data-id=\"4d7ebc5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1f090f4 elementor-widget elementor-widget-text-editor\" data-id=\"1f090f4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>This relaxation allows new behavioural strategies or insights to permeate. This explains why psychedelics have therapeutic potential in obsessive-compulsive disorders and addiction: the system that rigidly repeats normal behaviour and thoughts temporarily becomes less dominant, allowing you to tread new paths.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6723e02 e-flex e-con-boxed e-con e-parent\" data-id=\"6723e02\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-616cecb elementor-widget elementor-widget-heading\" data-id=\"616cecb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"hypothalamus\">Hypothalamus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a2a2736 e-grid e-con-boxed e-con e-parent\" data-id=\"a2a2736\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7b5d7e1 e-con-full e-flex e-con e-child\" data-id=\"7b5d7e1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1f23e29 elementor-widget elementor-widget-heading\" data-id=\"1f23e29\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Standard roll<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-d2430cc elementor-widget elementor-widget-text-editor\" data-id=\"d2430cc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Via the input of the cortex and limbic structures (especially the amygdala and hippocampus), psilocin indirectly influences the hypothalamus. As a result, physical sensations during a session may change: you can feel warmer or colder, less or more thirsty, or notice a shift in sexual energy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-c06abea e-con-full e-flex e-con e-child\" data-id=\"c06abea\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-0fd76dc elementor-widget elementor-widget-heading\" data-id=\"0fd76dc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-9e2516b elementor-widget elementor-widget-text-editor\" data-id=\"9e2516b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The hypothalamus has serotonergic innervation with, amongst others,. <strong data-start=\"5604\" data-end=\"5614\">5-HT\u2081A<\/strong> en <strong data-start=\"5618\" data-end=\"5628\">5-HT\u2082A<\/strong>-receptors, although the density is lower than in the cortex.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-64b6a02 e-con-full e-flex e-con e-child\" data-id=\"64b6a02\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-22ed61f elementor-widget elementor-widget-heading\" data-id=\"22ed61f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f1fc087 elementor-widget elementor-widget-text-editor\" data-id=\"f1fc087\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Via input from the cortex and limbic structures (especially the amygdala and hippocampus), psilocin indirectly affects the hypothalamus. As a result, physical sensations during a session can change: you may feel warmer or colder, more or less thirsty, or notice a shift in sexual energy.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cae4f86 e-con-full e-flex e-con e-child\" data-id=\"cae4f86\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-178c656 elementor-widget elementor-widget-heading\" data-id=\"178c656\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-17e3c51 elementor-widget elementor-widget-text-editor\" data-id=\"17e3c51\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Because the hypothalamus affects hormonal systems, psilocin can also the <strong data-start=\"6118\" data-end=\"6140\">HPA axis<\/strong> modulate. This can lead to feelings of relaxation and connectedness, as cortisol responses are dampened and oxytocin\/serotonin systems become more active. This explains the deep physical rest and safety that many users experience.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8e966a1 e-flex e-con-boxed e-con e-parent\" data-id=\"8e966a1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4aa3692 elementor-widget elementor-widget-heading\" data-id=\"4aa3692\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"amygdala\">Amygdala<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b1841f3 e-grid e-con-boxed e-con e-parent\" data-id=\"b1841f3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-8730d75 e-con-full e-flex e-con e-child\" data-id=\"8730d75\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-353230a elementor-widget elementor-widget-heading\" data-id=\"353230a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Standard roll<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-134d105 elementor-widget elementor-widget-text-editor\" data-id=\"134d105\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The amygdala forms the emotional centre of the brain and plays a crucial role in perceiving threat, regulating fear responses and linking emotions to memories. Through this function, the amygdala largely determines how intensely we experience events and how emotional experiences are stored in our memory.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-36ecd76 e-con-full e-flex e-con e-child\" data-id=\"36ecd76\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4e26cf5 elementor-widget elementor-widget-heading\" data-id=\"4e26cf5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c799154 elementor-widget elementor-widget-text-editor\" data-id=\"c799154\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The amygdala has both <strong data-start=\"6629\" data-end=\"6639\">5-HT\u2081A<\/strong> as <strong data-start=\"6644\" data-end=\"6654\">5-HT\u2082A<\/strong>-receptors that modulate its reactivity.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1d7c6ee e-con-full e-flex e-con e-child\" data-id=\"1d7c6ee\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f66f3d6 elementor-widget elementor-widget-heading\" data-id=\"f66f3d6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-46b5a67 elementor-widget elementor-widget-text-editor\" data-id=\"46b5a67\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>During the acute trip, amygdala activity often decreases, especially in response to emotionally negative stimuli. In healthy participants, this leads to a more positive mood. In patients with depression, it has been observed that in the days following the session, the amygdala actually <strong data-start=\"6991\" data-end=\"7021\">more emotionally responsive<\/strong> becomes. This is not in the sense of fear, but in the sense of openness to allow emotions.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-18a67ba e-con-full e-flex e-con e-child\" data-id=\"18a67ba\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-1f8e07f elementor-widget elementor-widget-heading\" data-id=\"1f8e07f\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b374e05 elementor-widget elementor-widget-text-editor\" data-id=\"b374e05\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>This two-phase effect makes therapy more powerful: during the session, anxiety is dampened, allowing you to dare to touch upon difficult themes. After the session, emotional responsiveness is restored, so that new insights are not suppressed but actually fully experienced.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-8dee86e e-flex e-con-boxed e-con e-parent\" data-id=\"8dee86e\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-6943f5a elementor-widget elementor-widget-heading\" data-id=\"6943f5a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"hippocampus\">Hippocampus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-353d218 e-grid e-con-boxed e-con e-parent\" data-id=\"353d218\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7632d48 e-con-full e-flex e-con e-child\" data-id=\"7632d48\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8b77188 elementor-widget elementor-widget-heading\" data-id=\"8b77188\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Standard roll<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-54e60bc elementor-widget elementor-widget-text-editor\" data-id=\"54e60bc\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The hippocampus is the memory centre of the brain and is responsible for recording new memories and placing them in the right context. In doing so, it gives events meaning by linking them to emotions, in close collaboration with the amygdala. At the same time, the hippocampus maintains intensive contact with the cortex, where memories are eventually stored in the long term. In this way, the hippocampus forms a link between experience in the moment and the lasting stories that determine our self-image and our life history.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-0a63a42 e-con-full e-flex e-con e-child\" data-id=\"0a63a42\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-98b8fc8 elementor-widget elementor-widget-heading\" data-id=\"98b8fc8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7a6e453 elementor-widget elementor-widget-text-editor\" data-id=\"7a6e453\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The hippocampus is rich in <strong data-start=\"7692\" data-end=\"7713\">5-HT1A receptor<\/strong> and also contains 5-HT\u2082A, albeit in lower concentrations than the cortex.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9e5ede9 e-con-full e-flex e-con e-child\" data-id=\"9e5ede9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4f650c3 elementor-widget elementor-widget-heading\" data-id=\"4f650c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3fa6c47 elementor-widget elementor-widget-text-editor\" data-id=\"3fa6c47\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Under the influence of psilocin, memories can be recalled and placed within a new emotional framework. This is accompanied by <strong data-start=\"7956\" data-end=\"7996\">rapid neuroplastic changes<\/strong>dendritic spine growth, increased BDNF expression and activation of the <strong data-start=\"8070\" data-end=\"8087\">mTOR\/TrkB pathway<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-51bf669 e-con-full e-flex e-con e-child\" data-id=\"51bf669\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-378c5d8 elementor-widget elementor-widget-heading\" data-id=\"378c5d8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3162332 elementor-widget elementor-widget-text-editor\" data-id=\"3162332\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The result is that old memories do not disappear, but their charge can change. Traumas can be re-experienced with greater gentleness, allowing the brain to create a new narrative around the same facts \u2013 a crucial step in psychotherapeutic recovery.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-6c7c1c9 e-flex e-con-boxed e-con e-parent\" data-id=\"6c7c1c9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-31bf64c elementor-widget elementor-widget-heading\" data-id=\"31bf64c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"thalamus\">Thalamus<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-3107cf7 e-grid e-con-boxed e-con e-parent\" data-id=\"3107cf7\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-7060651 e-con-full e-flex e-con e-child\" data-id=\"7060651\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8241d49 elementor-widget elementor-widget-heading\" data-id=\"8241d49\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Standard roll<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-804b856 elementor-widget elementor-widget-text-editor\" data-id=\"804b856\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The thalamus acts as a central relay station in the brain and determines which stimuli from the senses are passed on to the cortex. It filters sound, images, touches and internal signals so that only the most relevant information reaches our consciousness. The thalamus therefore plays a key role in attention and perception: it regulates whether we ignore a soft background noise or suddenly look up at an unexpected sound. As a gatekeeper between the outside world and conscious thought, the thalamus thus largely determines how we experience reality.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b0b349d e-con-full e-flex e-con e-child\" data-id=\"b0b349d\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fb2c413 elementor-widget elementor-widget-heading\" data-id=\"fb2c413\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3734ac8 elementor-widget elementor-widget-text-editor\" data-id=\"3734ac8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The thalamus has serotonergic receptors, but fewer than the cortex. Yet, due to its central position, it plays a massive role in the effects of psilocin.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-20a95e8 e-con-full e-flex e-con e-child\" data-id=\"20a95e8\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-a460df7 elementor-widget elementor-widget-heading\" data-id=\"a460df7\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-3dde795 elementor-widget elementor-widget-text-editor\" data-id=\"3dde795\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Psilocin disrupts the thalamic filter function, allowing more and more intense stimuli to reach the cortex. This explains why sound, colour and touch are experienced more intensely. It can also cause hallucinations, as irrelevant or internal signals enter conscious awareness unfiltered.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-55ed1b6 e-con-full e-flex e-con e-child\" data-id=\"55ed1b6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4807c79 elementor-widget elementor-widget-heading\" data-id=\"4807c79\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2c16922 elementor-widget elementor-widget-text-editor\" data-id=\"2c16922\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The increased permeability of the thalamus enhances the sensory richness of a trip and contributes to synaesthesia (when senses blend). This abundance of input feeds the neocortex, which attempts to integrate it meaningfully.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-4c95d7a e-flex e-con-boxed e-con e-parent\" data-id=\"4c95d7a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-10d3995 elementor-widget elementor-widget-heading\" data-id=\"10d3995\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"corpus-callosum\">Corpus callosum<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5ca3eab e-grid e-con-boxed e-con e-parent\" data-id=\"5ca3eab\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-38e1103 e-con-full e-flex e-con e-child\" data-id=\"38e1103\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7f819ef elementor-widget elementor-widget-heading\" data-id=\"7f819ef\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Standard roll<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-29a03b3 elementor-widget elementor-widget-text-editor\" data-id=\"29a03b3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The corpus callosum is a thick bundle of nerve fibres that connects the left and right cerebral hemispheres. Thanks to this structure, the hemispheres can continuously exchange information and complement each other's functions. The left hemisphere, which is often more heavily involved in language and analytical thinking, is thus coordinated with the right hemisphere, which is instead more specialised in creativity, intuition and holistic perception. The corpus callosum therefore ensures that reason and emotion, logic and imagination, do not function in isolation, but are woven together cohesively into a seamless whole.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-2618fbe e-con-full e-flex e-con e-child\" data-id=\"2618fbe\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9fb0234 elementor-widget elementor-widget-heading\" data-id=\"9fb0234\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-87bf953 elementor-widget elementor-widget-text-editor\" data-id=\"87bf953\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Although the fibres themselves do not contain receptors, the connected cortical regions are rich in 5-HT\u2082A.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-418e462 e-con-full e-flex e-con e-child\" data-id=\"418e462\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-981d404 elementor-widget elementor-widget-heading\" data-id=\"981d404\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-02c7ce1 elementor-widget elementor-widget-text-editor\" data-id=\"02c7ce1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Under psilocin, interhemispheric communication increases. People experience this as a fusion of reason and feeling, or as images directly connected to language and meaning.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-416e513 e-con-full e-flex e-con e-child\" data-id=\"416e513\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-384ecac elementor-widget elementor-widget-heading\" data-id=\"384ecac\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-6dd01c3 elementor-widget elementor-widget-text-editor\" data-id=\"6dd01c3\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>This increased integration gives rise to creative insights that make both logical and emotional sense \u2013 a rare synergy often experienced as a \u201crevelation\u201d.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d8998ec e-flex e-con-boxed e-con e-parent\" data-id=\"d8998ec\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-61f2e16 elementor-widget elementor-widget-heading\" data-id=\"61f2e16\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"cerebellum\">Cerebellum<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f5315d3 e-grid e-con-boxed e-con e-parent\" data-id=\"f5315d3\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-fde10ea e-con-full e-flex e-con e-child\" data-id=\"fde10ea\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-9fbc45d elementor-widget elementor-widget-heading\" data-id=\"9fbc45d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Standard roll<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-93a6135 elementor-widget elementor-widget-text-editor\" data-id=\"93a6135\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The cerebellum, also known as the little brain, is traditionally known as the centre that precisely coordinates movement and timing. It ensures that our actions unfold smoothly and precisely, from walking and writing to making music. Alongside this motor role, however, the cerebellum also appears to be involved in emotional regulation and cognitive predictions: it helps to estimate what is going to happen and thus contributes to responding smoothly to the environment. This means the cerebellum is not merely a motor organ, but a sophisticated regulator that brings body, emotion and thought into balance.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-619a020 e-con-full e-flex e-con e-child\" data-id=\"619a020\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5f6f868 elementor-widget elementor-widget-heading\" data-id=\"5f6f868\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-fd1fe83 elementor-widget elementor-widget-text-editor\" data-id=\"fd1fe83\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Serotonergic receptors are present, but the density is lower than in the associative cortex.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-5c07751 e-con-full e-flex e-con e-child\" data-id=\"5c07751\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-7865a18 elementor-widget elementor-widget-heading\" data-id=\"7865a18\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-70e17d4 elementor-widget elementor-widget-text-editor\" data-id=\"70e17d4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The cerebellum shows that movements can be experienced more smoothly and breathing more consciously. The subjective experience of time also changes because the internal clock is influenced.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1649b0f e-con-full e-flex e-con e-child\" data-id=\"1649b0f\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5e38739 elementor-widget elementor-widget-heading\" data-id=\"5e38739\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-c4097de elementor-widget elementor-widget-text-editor\" data-id=\"c4097de\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Through the connection with sensory and frontal networks, the cerebellum enhances physical harmony during a trip. This makes dance, breathing or meditation feel extra connected and meaningful.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-9e7b015 e-flex e-con-boxed e-con e-parent\" data-id=\"9e7b015\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef0f713 elementor-widget elementor-widget-heading\" data-id=\"ef0f713\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"brainstem-en-raphe\">Brainstem and raphe<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-f493c01 e-grid e-con-boxed e-con e-parent\" data-id=\"f493c01\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-487c04a e-con-full e-flex e-con e-child\" data-id=\"487c04a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-68ddc72 elementor-widget elementor-widget-heading\" data-id=\"68ddc72\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Standard roll<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-af5981a elementor-widget elementor-widget-text-editor\" data-id=\"af5981a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The raphe nuclei in the brainstem form the main source of serotonin in the brain. Widely branched serotonergic projections are sent from these nuclei to virtually all brain regions, meaning they play a central role in mood, sleep, pain perception and emotional regulation. The brainstem itself also regulates fundamental bodily functions such as respiration, heart rate and the level of wakefulness or arousal. Together, the raphe nuclei and surrounding structures ensure that our brain can function in a stable physiological and emotional state, as a foundation upon which higher cognitive and emotional processes build.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-96afee1 e-con-full e-flex e-con e-child\" data-id=\"96afee1\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-c47964e elementor-widget elementor-widget-heading\" data-id=\"c47964e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1a7703a elementor-widget elementor-widget-text-editor\" data-id=\"1a7703a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The raphe contains <strong data-start=\"11088\" data-end=\"11113\">5-HT1A autoreceptors<\/strong>, which regulate their own firing rate.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b2bba3a e-con-full e-flex e-con e-child\" data-id=\"b2bba3a\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-63a9613 elementor-widget elementor-widget-heading\" data-id=\"63a9613\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-e37c7b4 elementor-widget elementor-widget-text-editor\" data-id=\"e37c7b4\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Psilocin activates these autoreceptors, causing the natural release of serotonin to drop temporarily. At the same time, it activates 5-HT\u2082A receptors elsewhere, leading to a brain-wide change in signal transmission.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-a8a2da9 e-con-full e-flex e-con e-child\" data-id=\"a8a2da9\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-8aba054 elementor-widget elementor-widget-heading\" data-id=\"8aba054\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7313931 elementor-widget elementor-widget-text-editor\" data-id=\"7313931\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>This explains why psilocin is not simply a \u201cserotonin boost\u201d, but a complete reconfiguration of serotonergic balance. Through connections with the nucleus tractus solitarius, this also influences the autonomic nervous system, which translates to altered heart rate, breathing, and feelings of relaxation or surrender.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-d2f9128 e-flex e-con-boxed e-con e-parent\" data-id=\"d2f9128\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-fa34ae2 elementor-widget elementor-widget-heading\" data-id=\"fa34ae2\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"vagus-nerve\">Vagus nerve<\/h2>\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-362fac0 e-grid e-con-boxed e-con e-parent\" data-id=\"362fac0\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t<div class=\"elementor-element elementor-element-92f11f6 e-con-full e-flex e-con e-child\" data-id=\"92f11f6\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5dc31ff elementor-widget elementor-widget-heading\" data-id=\"5dc31ff\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Standard roll<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-1125212 elementor-widget elementor-widget-text-editor\" data-id=\"1125212\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The vagus nerve is the tenth cranial nerve and forms an essential connection between the brain and the body. It sends signals from organs such as the heart, lungs and intestines to the brain and vice versa. The ventral branch normally promotes social engagement, calm and safety, whereas the dorsal branch plays a role in immobilisation and energy conservation, for example during extreme stress or deep relaxation.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b5ff135 e-con-full e-flex e-con e-child\" data-id=\"b5ff135\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f1deecb elementor-widget elementor-widget-heading\" data-id=\"f1deecb\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">receptor density<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a568efd elementor-widget elementor-widget-text-editor\" data-id=\"a568efd\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>There are few serotonergic receptors located within the vagus nerve itself. Yet, this nerve has a strong connection with brain regions that are rich in 5-HT\u2082A receptors, such as the insula, the anterior cingulate cortex and the prefrontal cortex. Via these brain regions, vagal activity can be influenced indirectly. This explains why serotonergic substances such as psilocin have a perceptible effect on the autonomic functions that the vagus nerve controls.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-1421ffb e-con-full e-flex e-con e-child\" data-id=\"1421ffb\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-5b02f54 elementor-widget elementor-widget-heading\" data-id=\"5b02f54\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Effects of psilocin<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-295a2ae elementor-widget elementor-widget-text-editor\" data-id=\"295a2ae\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>Psilocin primarily activates the 5-HT\u2082A receptors, altering communication patterns in brain regions associated with the vagus nerve. As a result, the ventral vagus becomes more active, leading to feelings of warmth, love, connectedness and safety. At higher doses, the balance can shift and the dorsal vagus becomes more involved, which can lead to a state of surrender and immobilisation. Many people experience this as a form of \u201cego death\u201d, in which the boundaries of the self temporarily dissolve.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-b1328cd e-con-full e-flex e-con e-child\" data-id=\"b1328cd\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-f762d75 elementor-widget elementor-widget-heading\" data-id=\"f762d75\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h5 class=\"elementor-heading-title elementor-size-default\">Side effects<\/h5>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-b7b25c1 elementor-widget elementor-widget-text-editor\" data-id=\"b7b25c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The first step is the enhanced serotonergic activity in brain regions that regulate the vagus nerve. This translates to increased ventral vagal activity and a physiological state of safety. From there, a cascade of effects follows: relaxation of heart rate and respiration, a greater sense of connection with others, and a deep physical feeling of calm. At higher doses, a shift towards dorsal vagal dominance occurs, which can manifest as physical surrender or a trance-like state. This combination of phases explains why psilocin can evoke both loving connection and transcendent letting go.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-ffe6e12 e-flex e-con-boxed e-con e-parent\" data-id=\"ffe6e12\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ef087ab elementor-widget elementor-widget-heading\" data-id=\"ef087ab\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"conclusie\">Conclusion<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f2d883 elementor-widget elementor-widget-text-editor\" data-id=\"7f2d883\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>The journey that psilocin triggers in the brain is not limited to a single region, but rather arises from the collaboration of many areas. By loosening the neocortex from its rigid patterns, causing the amygdala to react with less anxiety, placing old memories in a new light in the hippocampus, and having the vagus nerve enhance feelings of connectedness, a unique state of consciousness is created. This temporary reconfiguration of the brain opens the door to greater flexibility in thinking and feeling, and can lead to deep insights, emotional processing and lasting neuroplastic changes. That explains why psilocybin not only evokes a remarkable experience, but also has such great therapeutic potential for personal growth and recovery.<\/p><p>Anyone wishing to learn more about how these changes are subjectively experienced can read further in our article on the truffle journey. For a deeper dive into the effects of psilocybin and psilocin at the cellular level, we refer you to the article Psychotherapy is often unnecessary in psychedelic therapy. In this way, you gain insight into both the inner experience and the biological basis of these remarkable substances.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-65e3527 e-flex e-con-boxed e-con e-parent\" data-id=\"65e3527\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-ff58255 elementor-widget elementor-widget-button\" data-id=\"ff58255\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/the-truffle-trip\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Subjective experience<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-57f9fd9 elementor-widget elementor-widget-button\" data-id=\"57f9fd9\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/psychotherapie-psychedelische-therapie-niet-nodig\/\" target=\"_blank\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Psychedelics without therapy<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-cee161c e-flex e-con-boxed e-con e-parent\" data-id=\"cee161c\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t\t<div class=\"e-con-inner\">\n\t\t\t\t<div class=\"elementor-element elementor-element-4175793 elementor-widget elementor-widget-heading\" data-id=\"4175793\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-default\" id=\"zelf-ervaren-onder-begeleiding\">Experience it yourself with guidance<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2b553b0 elementor-widget elementor-widget-text-editor\" data-id=\"2b553b0\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t\t\t\t\t\t<p>At Triptherapie you can experience the effects of psilocybin and psilocin in a safe and meaningful way under the guidance of an experienced therapist or tripsitter. There are two steps you need to take to make an appointment. The first step is to fill in the intake form, so that we can clearly map out your health, intentions, and wishes. The second step is to choose and book the session that suits you best, after which we will shape the rest of the journey together.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t<div class=\"elementor-element elementor-element-456e6ba e-con-full e-flex e-con e-child\" data-id=\"456e6ba\" data-element_type=\"container\" data-e-type=\"container\">\n\t\t\t\t<div class=\"elementor-element elementor-element-40f425e elementor-align-center elementor-widget elementor-widget-button\" data-id=\"40f425e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/psychedelic-therapy-intake\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-fas-user-plus\" viewbox=\"0 0 640 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M624 208h-64v-64c0-8.8-7.2-16-16-16h-32c-8.8 0-16 7.2-16 16v64h-64c-8.8 0-16 7.2-16 16v32c0 8.8 7.2 16 16 16h64v64c0 8.8 7.2 16 16 16h32c8.8 0 16-7.2 16-16v-64h64c8.8 0 16-7.2 16-16v-32c0-8.8-7.2-16-16-16zm-400 48c70.7 0 128-57.3 128-128S294.7 0 224 0 96 57.3 96 128s57.3 128 128 128zm89.6 32h-16.7c-22.2 10.2-46.9 16-72.9 16s-50.6-5.8-72.9-16h-16.7C60.2 288 0 348.2 0 422.4V464c0 26.5 21.5 48 48 48h352c26.5 0 48-21.5 48-48v-41.6c0-74.2-60.2-134.4-134.4-134.4z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Online intake<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-2545042 elementor-align-center elementor-widget elementor-widget-button\" data-id=\"2545042\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t\t\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-sm\" href=\"https:\/\/triptherapie.nl\/en\/reservations\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t<span class=\"elementor-button-icon\">\n\t\t\t\t<svg aria-hidden=\"true\" class=\"e-font-icon-svg e-far-calendar-alt\" viewbox=\"0 0 448 512\" xmlns=\"http:\/\/www.w3.org\/2000\/svg\"><path d=\"M148 288h-40c-6.6 0-12-5.4-12-12v-40c0-6.6 5.4-12 12-12h40c6.6 0 12 5.4 12 12v40c0 6.6-5.4 12-12 12zm108-12v-40c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v40c0 6.6 5.4 12 12 12h40c6.6 0 12-5.4 12-12zm96 0v-40c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v40c0 6.6 5.4 12 12 12h40c6.6 0 12-5.4 12-12zm-96 96v-40c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v40c0 6.6 5.4 12 12 12h40c6.6 0 12-5.4 12-12zm-96 0v-40c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v40c0 6.6 5.4 12 12 12h40c6.6 0 12-5.4 12-12zm192 0v-40c0-6.6-5.4-12-12-12h-40c-6.6 0-12 5.4-12 12v40c0 6.6 5.4 12 12 12h40c6.6 0 12-5.4 12-12zm96-260v352c0 26.5-21.5 48-48 48H48c-26.5 0-48-21.5-48-48V112c0-26.5 21.5-48 48-48h48V12c0-6.6 5.4-12 12-12h40c6.6 0 12 5.4 12 12v52h128V12c0-6.6 5.4-12 12-12h40c6.6 0 12 5.4 12 12v52h48c26.5 0 48 21.5 48 48zm-48 346V160H48v298c0 3.3 2.7 6 6 6h340c3.3 0 6-2.7 6-6z\"><\/path><\/svg>\t\t\t<\/span>\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Book<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>","protected":false},"excerpt":{"rendered":"<p>Discover how psilocybin affects the brain and why this leads to profound changes in emotion, memory and consciousness. Psilocybin activates the neocortex, causing patterns and perceptions to be experienced differently. In the anterior cingulate gyrus, it enhances emotional processing and self-reflection, whilst in the caudate nucleus flexibility and new behaviour are promoted. The hypothalamus responds with changes in hormonal balance and body regulation. In the amygdala, psilocybin reduces the anxiety response and increases emotional openness. The hippocampus receives a boost in memory processing and the formation of new connections. Via the thalamus, the filter of sensory information changes, making experiences more intense. The corpus callosum promotes greater communication between the brain hemispheres. The cerebellum supports an altered body sense and coordination. The brainstem and raphe nuclei, which produce serotonin, play a key role in mood and consciousness. Finally, psilocybin enhances signals from the vagus nerve, which increases feelings of connectedness, safety and relaxation.<\/p>","protected":false},"author":1,"featured_media":53561,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[62],"tags":[],"class_list":["post-53394","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-nieuws"],"_links":{"self":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/posts\/53394","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/comments?post=53394"}],"version-history":[{"count":0,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/posts\/53394\/revisions"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/media\/53561"}],"wp:attachment":[{"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/media?parent=53394"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/categories?post=53394"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/triptherapie.nl\/en\/wp-json\/wp\/v2\/tags?post=53394"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}