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New addition to the Opium Act List 1A

Which MDMA analogues will become illegal as of July 1, 2025, due to the amended Opium Act?
To the answer

Why the new NPS law?

The government introduced the NPS Act because the original list approach was no longer sufficient to curb the rapid rise of new psychoactive substances ("legal highs" or "designer drugs"). Instead of placing each individual substance on the Opium List, the Netherlands will use a broad, generic definition effective July 1, 2025, that will directly prohibit entire groups of chemically related substances.

The main objectives of this legislation are:

  1. Prevention and public health
    By banning groups of substances with similar chemical structures (such as phenethylamines, cathinones, and benzofuran analogs) in one fell swoop, the government aims to reduce the supply and use of potentially dangerous new substances. This is a preventative measure: not waiting for damage to occur, but preventing such substances from entering circulation.

  2. Be ready before the producer
    Designer drug manufacturers are constantly tweaking their molecules to remain legal. With the generic approach, it's impossible to successfully play these cat-and-mouse games: every new variant within the defined substance groups is immediately banned.

  3. International pressure and harmonization
    The Netherlands was known as a safe haven for NPS producers, who exported their substances from here to countries where they were already illegal. Pressure from Europe and from the police and the Public Prosecution Service made it clear that a generic approach was needed. This way, our policy aligns with that of other Member States and cross-border trade can be combated more effectively.

  4. Taking more effective action against trade and production
    Police and law enforcement agencies can now take faster action against both imports and local production, without waiting for individual risk assessments for each substance. This accelerates criminal prosecution and reduces administrative burden.

In short, the NPS Act no longer focuses on individual chemical names, but on the underlying structures. With this, the government aims to stay ahead of new psychoactive substances, protect public health, and prevent the Dutch market from serving as a base for the export of designer drugs.

Opium Act amendment

Banned MDMA analogues as of July 1, 2025

From July 1, 2025 The new generic IA list of the Opium Act not only includes MDMA and its immediate relatives, but also all of the following:, phenylethylaminen, cathinones, and benzofurans. This means that the following substances, among others, are permanently banned:

Phenylethylamines

  • 3-FPM (3-fluorophenmetrazine)

  • 2C-D (2,5-dimethoxy-4-methylphenethylamine)

  • 2C-E (2,5-dimethoxy-4-ethylphenethylamine)

  • 2C-C (2,5-dimethoxy-4-chlorophenethylamine)

  • 2C-G (2,5-dimethoxy-3,4-dimethylphenethylamine)

  • 2C-E-NBOMe (N-(2-methoxybenzyl)-2C-E)

  • 2C-B-FLY (2,3,6,7-tetrahydro-benzofuran-4-yl-2,5-dimethoxyphenethylamine)

  • BK-2C-B (β-keto-2C-B)

  • BOH-2C-B (β-hydroxy-2C-B)

  • Metallylescaline (3,4,5-trimethoxy-2-methallylphenethylamine)

  • 4-BMC (4-bromomethcathinone)

  • 4-MPM (4-methylphenmetrazine)

  • 4B-MAR (4-bromo-2,5-dimethoxyaminorex)

Phenylethylamine molecule
Cathinones

  • 2-MMC (2-methylmethcathinone)

  • FAKE (N-ethylpentedron)

  • MDPHP (3,4-methylenedioxy-α-pyrrolidin-hexan-one)

  • 3FMC (3-fluoromethcathinone)

  • 3MMA (3-methylmethcathinone)

  • MDPiHP (3,4-methylenedioxy-α-pyrrolidin-isopentyl-one)

  • α-BPVP (α-pyrrolidinobutyrophenone)

  • MF-PVP (4′-fluoro-α-pyrrolidinovalerofenone)

cathinone molecule
Benzofurans

  • 6-APB (6-(2-aminopropyl)benzo[f]uran)

  • 6-API (2-Aminoethyl)benzofuran)

  • 5-APB (5-(2-Aminopropyl)benzofuran)

  • 5-MAPB (5-(2-aminopropyl)benzo[d][1,3]dioxole)

  • 5-DBFPV (5-(2,3-dihydrobenzofuran-5-yl)-2-pyrrolidin-1-ylpentan-2-one)

  • 5-MBPB (5-Methyl-1-benzofuran-5-yl-N-methylbutan-2-amine)

benzofuran molecule

What if you still have the substances in your possession after July 1?

If you purchased these MDMA analogs before July 1, 2025, and still possess them, you are liable to prosecution. However, using them is not illegal, and in theory, you should collect your entire supply by the time the night of July 1st begins to avoid breaking the law. Of course, the point of such a transitional arrangement is the law, but you really don't have to. not to “consume” everything in one night to remain legal. 

What you can do:

  • Hand in at the police or a government-approved drug waste collection point.

  • Destruction via a chemical waste processor (for example LCRs or municipal collection days).

  • Destruction at home (for small quantities): Mix with insoluble, unusable material (e.g. coffee grounds), place in a tightly sealed container and dispose of with household waste – never down the sink or toilet.

MDMA therapy with own MDMA or analogue

If you do come into possession of these substances after July 1st, at your own risk, and wish to use them on your own initiative, we can support you with a guided session. According to the Opium Act Criminal Procedure Guidelines, Hard Drugs (2019R011), the Public Prosecution Service considers a quantity of up to 0.5 grams (or one pill) a "small quantity" for personal use. Such quantities are generally seized but rarely lead to prosecution. However, for larger quantities, you should be aware of criminal prosecution.

We do not refuse clients who choose to bring a maximum of 500 mg of their own MDMA or an analog to a session. We do this to limit the risks for users (harm reduction). During the guided session, we act as a trip sitter: we offer professional support and help you with safety, but are not responsible for the origin or quality of the substance. We do ask that all substances are tested beforehand and that you clearly indicate that you are bringing your own initiative and that the substances are yours for and for yourself, so that the role of the guide remains pure and legal.

MDMA therapy
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