Is it safe to take psilocybin on ssris?

@stubbe 

Geplaatst door: @stubbe

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Is it safe to take psilocybin on ssris?

It is possible to do psilocybin sessions while on SSRI's. Recent research showed there was not a big elevated risk on the serotonin syndrome as was thought before. Here are some thinks to consider:

Reduced Psychedelic Effects

SSRIs (e.g., sertraline, fluoxetine) often diminish the subjective effects of psilocybin. This is because chronic SSRI use can downregulate serotonin receptors (particularly 5-HT2A), which psilocybin activates to produce its psychedelic effects.

As a result, individuals on SSRIs may experience a "blunted" or less intense trip, which could lead some to take higher doses of psilocybin to compensate. Increasing the dose raises risks of anxiety, confusion, or overwhelming psychological experiences.

Serotonin Syndrome Risk Is Low

Unlike combinations involving MAOIs or other serotonergic drugs, psilocybin and SSRIs are unlikely to cause serotonin syndrome. Psilocybin acts primarily as a serotonin receptor agonist (mimicking serotonin) rather than increasing serotonin release or blocking its reuptake.

However, caution is still advised if combining psilocybin with other serotonin-affecting substances (e.g., SNRIs, tramadol, or MDMA).

Mental Health Implications

Psilocybin can evoke intense emotional states. For individuals managing depression, anxiety, or other conditions with SSRIs, an unguided psychedelic experience might exacerbate symptoms or destabilize mood.

Abruptly stopping SSRIs to "feel" psilocybin’s effects is not recommended, as it can trigger withdrawal symptoms (e.g., dizziness, mood swings, "brain zaps") and relapse of underlying mental health issues.

Limited Research

Most clinical trials on psilocybin exclude SSRI users, so safety and efficacy data are sparse. Anecdotal reports suggest variability—some people notice no interaction, while others describe muted trips or emotional numbness.

Recommendations

Consult a Healthcare Provider: Always discuss psychedelic use with a doctor or mental health professional, especially if you’re on SSRIs. They can help weigh risks and monitor your medication regimen.

Avoid Self-Dosing: Do not increase psilocybin doses to overcome SSRI-related blunting. This raises the risk of adverse psychological reactions.

Guided Sessions Over Recreational Use: If exploring psilocybin therapeutically, seek support from a trained facilitator that we offer,

Conclusion

While combining psilocybin and SSRIs is probably not causing serotonin syndrome, SSRIs often reduce psilocybin’s effects, creating a risk of unsafe dosing or psychological distress. Prioritize open communication with a healthcare provider and avoid self-guided experimentation. Emerging research may clarify this interaction, but for now, caution and professional oversight is recommended.