Table of contents
What is psilocybin?
Psilocybin is an increasingly well-known psychedelic. It owes its name to the mushrooms in which it occurs, of the genus Psilocybe. The molecular structural formula is C12H17N2O4P and this substance is also known as O-phosphoryl-4-hydroxy-N,N-dimethyltryptamine or indocybin. Psilocybin occurs in varying amounts in mushrooms that are found on all continents except Antarctica. Many people know psilocybin for its psychedelic and hallucinogenic effect
The metabolism of psilocybin
When psilocybin enters the body, it is first converted into psilocin by dephosphorylation of the phosphate group present. The dephosphorylation of psilocybin is a chemical process in which the phosphate group is removed from the psilocybin molecule. Psilocybin itself is the most well-known alkaloid found in magic mushrooms and magic truffles. The process of dephosphorylation can occur under certain conditions.
The main way in which dephosphorylation occurs is by the enzyme phosphatase. Phosphatase is a naturally occurring enzyme of the human body and is produced in the liver. This enzyme can hydrolyze the phosphate group, converting psilocybin into psilocin, the active psychoactive ingredient. As soon as psilocybin is absorbed through the intestines, it will first be converted by the liver via the portal vein.
Acidic environments such as the human body and especially the stomach can also cause psilocybin to be converted to psilocin.
The activity of psilocybin and psilocin
If psilocybin were not converted to psilocin, then psilocybin would hardly be psychoactive. For example, psilocin is very active on the 5-HT2B receptor with an inhibitory constant of 4.6 Ki (the lower the constant the more binding/activity) and psilocybin has a value of 98.7 Ki. Psilocybin is also virtually inactive on the important 5-HT2A receptor and also inactive on the 5-HT1A receptors. Psilocin does have an effect on the 2A and 1A receptors. The affinity and ability to bind with these receptors is important when it comes to the psychoactive effects of these substances. If we rank the strength of psilocin on the serotonin receptors, the highest is 5-HT2A, then 5-HT2B and then 5-HT1A.
What does psilocin do on these 5-HT receptors?
Psilocin is therefore a partial agonist of the 5-HT1A receptor, which means that it is able to bind to and partially activate this receptor. Activation of this receptor can produce anxiolytic (anxiety-reducing) and antidepressant effects. The 5HT1A receptor is also involved in regulating autonomic functions such as heart rate, body temperature and endocrine functions.
However, high stimulation can also cause side effects, including nausea and dizziness, which are common during use.
High stimulation of the 5-HT2A receptor is associated with psychedelic experiences, including visual or auditory hallucinations, a heightened sense of consciousness and an altered sense of time.
For the time being, the 5-HT2A receptor is seen as the most important when it comes to psychedelic effects. Stimulation of this receptor is also associated with increased BDNF concentrations and thus increased neuroplasticity.
The 5-HT2B receptor plays a role in the regulation of blood pressure and heart rate. One of the best known functions of the 5-HT2B receptor is its involvement in the growth and development of heart valves during embryonic development.
Psilocin's affinity for the 5-HT2B receptor is likely lower than for the 5-HT2A receptor, meaning that its psychedelic effects are mainly mediated through the 5-HT2A receptor.
The subjective experience
Users who take a lot of psilocybin sometimes talk about an ego death. Ego death mainly has to do with diminishing sense of self. The effects described in the video are the effects that people can have on a high dose of psilocybin.
It is also possible to experience an ego death without using psychedelic substances, such as deep meditation/breathwork or anything else that can bring you into the flow. There are also many similarities with a near-death experience.
Psilocybin and science
Over the last two decades, psilocybin has attracted interest as a potential therapeutic agent for the treatment of various mental health conditions such as depression, anxiety and addiction.
Studies have shown that psilocybin can cause long-lasting positive changes in mood and behavior. Scientific researchers are now conducting many clinical trials to investigate how psilocybin can be used in more and more areas. Psilocybin is found to work very well, especially for depression.
More studies are currently underway and psilocybin is being tested to see whether it can provide relief for several complaints. Here is an overview of topics.
- Alcoholism (AUD, alcohol use disorder)
- Smoking addiction
- Opioid addiction
- Major depression (depressive disorder Major)
- Therapy resistant depression
- Anxiety complaints
- Obsessive-Compulsive Disorder (OCD)
- Body Dysmorphic Disorders (BDD)
- Cluster headache
Psilocybin therapy in the Netherlands
Psilocybin therapy is an experimental psychedelic treatment that is not currently recognized as a formal medical treatment. This means that patients interested in this treatment will have to cover their own costs, as insurers do not currently provide coverage for this therapy. Although the effectiveness of this treatment has been demonstrated for a number of mental conditions, more research is needed before this therapy is widely accepted as a legitimate form of treatment.
Dutch law does allow room for psilocybin sessions that are done with legal magic truffles that also contain psilocybin. The psilocybin sessions we offer are in fact truffle sessions. Read more about our psilocybin therapy via the button.
Terms related to psilocybin therapy
Every time someone in the Netherlands talks about a psilocybin ceremony or a mushroom, shroom or truffle session, psilocybin is involved. All these terms that are clearly related to the hallucinatory effect of psilocybin and therefore psilocin are used interchangeably. In the Netherlands you can say that when researchers refer to psilocybin, they used pure psilocybin in the studies. In the case of the current legal psilocybin or magic mushroom therapy/session, legal magic truffles containing psilocybin and psilocin are usually used.
Below we answer the most frequently asked questions about psilocybin and whether it is legal to buy and how psilocybin therapy works. Is your answer not listed? Feel free to ask your question via the contact form or via the forum via the buttons below.
What does psilocybin do to you?
Psilocybin, after conversion to psilocin, has several effects on the user, including hallucinations, changes in perception, increased sensitivity to sensory stimuli, and changes in the sense of time and space. It can also lead to altered emotions and mood, introspection and spiritual experiences.
The effects of psilocybin vary depending on dosage, individual sensitivity and environmental factors. Using psilocybin can also pose risks, such as confusion, anxiety or panic attacks, and it is therefore essential to exercise caution and consider the possible consequences.
How do I get psilocybin?
What are psilocybin drops?
Is psilocybin banned?
Can I microdose psilocybin?
Is psilocybin therapy already possible?
Do health insurers reimburse psilocybin treatment?
How does a guided psilocybin trip work?
The exact course of a guided psilocybin session can vary depending on the counselor/therapist and the specific needs of the person. In general, the session takes place in a quiet and comfortable environment such as our location or in your own home. The therapist will inform you prior to the session about what to expect and answer any questions you may have.
During the session you take a dose of psilocybin (in the form of magic truffles). The therapist will guide you through the effect of the psilocybin, supporting you in exploring your thoughts, emotions and experiences. They may conduct conversations, offer guided meditations, or use other techniques to help you gain insights and process any problems you may have.
The purpose of a guided trip session is to increase therapeutic effects, such as increasing self-awareness, exploring repressed emotions, reducing anxiety or depression, and promoting personal growth and well-being. A therapist or supervisor also ensures physical safety and helps with preparation and integration.